Dr. Cannon holds a Career Development Award No. HE-15031. Dr. Heinemann is a Career Scientist, Health Research Council of the City of New York (I-189). Address requests for reprints to Dr. Roberta M. Goldring, New York University School of Medicine, 550 First Avenue, New York 10016. Received for publication 20 January 1967 and in revised form 7 September 1967. when renal hydrogen ion excretion ...

In 11 normally oxygenated, normotensive mongrel dogs, blood flow and oxidative metabolism of the brain was studied during normocapnia and during respiratory alkalosis and respiratory acidosis. During respiratory alkalosis (mean PaCO2 17.8 mm Hg) CBF decreased significantly from 61.0 to 33.9 ml/100 g/min (44%) while arteriovenous-substrate differences increased and the rates of oxygen and glucos...

Acid/base homeostasis is one of the most difficult subdisciplines of physiology for medical students to master. A different approach, where theory and practice are linked, might help students develop a deeper understanding of acid/base homeostasis. We therefore set out to develop a laboratory exercise in acid/base physiology that would provide students with unambiguous and reproducible data tha...

HAGGIE, S.J., FERMONT, D.C. & WYLLIE, J.H. (1976) Treatment of duodenal ulcer with cimetidine. Lancet, i, 983. HARKEN, A.H., GABEL, R.A., FENEL, V. & MOORE, F.D. (1975). Hydrochloric acid in the correction of metabolic alkalosis. Archives of Surgery, 110, 819. HERTZ, P. & RICHARDSON, J.A. (1972) Arginine-induced hyperkalemia in renal failure patients. Archives of Internal Medicine, 130, 778. KA...

pH is one of the most important physiological parameters, with its changes affecting the function of vital organs like the heart. However, the effects of alkalosis on the regulation of cardiac myocyte function have not been extensively investigated. Therefore, we decided to study whether the mitogen-activated protein kinase (MAPK) signaling pathways [c-Jun NH2-terminal kinases (JNKs), extracell...

To the Editor:—Metabolic alkalemia is the most common acid–base disturbance among patients in the hospital. Because the disorder is associated with high mortality and morbidity, its prompt diagnosis and treatment is feasible. The expected physiologic compensation for a primary increase in serum bicarbonate concentration ([HCO3 ]), i.e., metabolic alkalosis, is hypoventilation that increases par...

Hypobaric hypoxia causes hypocapina and alkalosis, hemoconcentration and increased hematocrit, and a decreased cardiac stroke volume. To assess the role of the hypocapnic alkalosis in causing these other changes, five men were exposed to hypobaric hypoxia at a barometric pressure (PB) of 440 torr with an alveolar O2 tension of 55 torr for 5 days with 3.77% CO2 added to the atmosphere to prevent...

Objective. Cyclosporine (CsA) causes tubular dysfunction characterized by polyuria, calcium wasting, distal tubular acidosis, and hyperkalemia. The hypercalciuria induced by CsA administration is associated with an inhibition of calbindin D28k expression. It has also been shown that chronic metabolic alkalosis increased the expression of Ca transport proteins accompanied by diminished urine Ca ...

A case of a 66-year-old white man with recent onset of oedema, hypertension, metabolic alkalosis and profound hypokalaemia is described. The initial laboratorial workup showed that urinary chloride concentration and potassium excretion were increased, suggesting a state of hyperaldosteronism. Nonetheless, renin activity was low and aldosterone levels were normal. The metabolic alkalosis seen in...