Inflammation is a constant in Non-Alcoholic Fatty Liver Disease (NAFLD), although their relationship unclear. In transgenic zebrafish system with chronic systemic overexpression of human IL6 (IL6-OE) we show that inflammation can cause intra-hepatic accumulation triglycerides. Transcriptomics and proteomics analysis the IL6-OE liver revealed deregulation glycolysis/gluconeogenesis pathway, espe...

Objectives: To investigate the prevalence of NAFLD as well as the determination of associated metabolic abnormalities in Iranian blood donors. The aim of this study was to review cases of nonalcoholic fatty liver disease and to determine the prevalence of non-alcoholic fatty liver disease as a cause of elevated alanine aminotransferase in healthy blood donors and also assess risk factors of NAF...

Submit Manuscript | http://medcraveonline.com Abbreviations: ALT: Alanine Amino Transferases; AST: Aspartate Amino Transferases; AUROC: Area Under the Receiver Operating Characteristic Curve; BMI: Body Mass Index; CIT: Cold Ischemia Time; CT: Computed Tomography; D-MELD: Donor Age Multiplied with the Recipient Model for End-Stage Liver Disease; ECD: Extended Criteria Donor; EGD: Early Graft Dys...

Diabetics have a higher risk of developing nonalcoholic fatty liver disease (NAFLD) and associated complications than the general population. The purpose this study was to determine prevalence Non-Alcoholic Fatty Liver Disease in patients with type 2 diabetes, as well demographic, metabolic, biochemical features it. Material methods: This prospective, observational, descriptive (cross-sectional...

Non-alcoholic steatohepatitis (NASH) and alcoholic steatohepatitis (ASH) have a similar pathogenesis and histopathology but a different etiology and epidemiology. NASH and ASH are advanced stages of non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD). NAFLD is characterized by excessive fat accumulation in the liver (steatosis), without any other evident causes of...

Non-alcoholic fatty liver disease (NAFLD) is a major cause of worldwide, affecting up to 30% adults. Progression non-alcoholic steatohepatitis (NASH) key risk factor for cirrhosis, hepatocellular carcinoma and cardiovascular events. Alterations in reproductive hormones are linked the development and/or progression NAFLD/NASH women. Women with Polycystic Ovary Syndrome (PCOS) those estrogen defi...

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is the most common hepatic disorder, which poses a significant health burden in the western countries. As the epidemic of obesity slides health downward, the incidence of NAFLD is evidently increasing. AIM We aimed to ascertain the awareness of NAFLD and its risk factors in the general population, which may be helpful in designing education...

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in developed countries. Obesity is the most important risk factor for metabolic syndrome and NAFLD. Accumulated evidence has revealed that gut microbial compositional changes may be associated with more energy harvesting from the diet, which promotes increased fatty acid uptake from adipose tissue and shifts l...

Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in Western countries in which men and women are affected equally (de Alwis and Day 2008; Willner et al. 2001). The prevalence and severity of NAFLD increase with obesity (Flegal et al. 1998 & 2003). Since obesity is known to have a genetic etiology, we propose that genetic factors influence susceptibility...