Optic nerve transection (ONT) triggers retinal ganglion cell (RGC) death. By using this paradigm, we have analyzed for the first time in adult albino and pigmented mice, the effects of ONT in the scotopic threshold response (STR) components (negative and positive) of the full-field electroretinogram. Two weeks after ONT, when in pigmented mice approximately 18% of the RGC population survive, th...

The role of retinal microglial cells (MCs) in age-related macular degeneration (AMD) is unclear. Here we demonstrated that all retinal MCs express CX3C chemokine receptor 1 (CX3CR1) and that homozygosity for the CX3CR1 M280 allele, which is associated with impaired cell migration, increases the risk of AMD. In humans with AMD, MCs accumulated in the subretinal space at sites of retinal degenera...

In the present study, the safety profile of Trichosanthes dioica root was evaluated by acute and sub-chronic toxicity study of the hydro alcoholic extract of T. dioica root (TDA) in Swiss albino mice. The oral median lethal dose (LD ) of TDA was found to be 2800 mg/kg body weight. For sub-chronic toxicity study 50 TDA was administered at the single daily dose of 10 mg/kg for 28 consecutive days...

Twelve, male albino mice, aged 6-8 weeks, were injected intraperitoneally, aqueous solution of gentamicin (80 mg / kg / day) for fifteen days and the effects observed on the kidney structure and function. Group A served as control while Group B was given gentamicin. At the end of the experiment, blood was drawn from each animal by cardiac puncture for renal function tests and kidneys were fixed...

the effects of chronic administration of lithium, on acute toxicity of carbamazepine (cbz) in mate albino mice was studied and the ld50 values were determined from dose-probit curves. the results showed that in lithium pretreated animals (animals consumed drinking water contraining 600 mg/l lithium carbonate for 10 days) the ld50 value (the doese corresponding to probit 5) of cbz decreased sign...

Zinc oxide (ZnO) nanoparticles have received growing attention for several biomedical applications. Nanoparticles proposed for these applications possess the potential to interact with biological components such as the blood, cells/ tissues following their administration into the body. Hence we carried out in vivo investigations in Swiss Albino Mice to understand the interaction of ZnO nanorods...

This study aimed to investigate the effects of flavonoid glycoside on mitochondrial dysfunction and inflammatory oxidative stress in macular degeneration. Sixty specific-pathogen-free male Bagg Albino mice were randomly divided into control, model glycoside. Human retinal pigment epithelium cells ARPE-19 cultured treated with dimethyl sulfoxide, sodium iodate respectively. Fundus fluorescein an...

Diabetic neuropathy is a nerve disorder manifested by different faceted condition affecting up to half of individuals with persistent diabetes. Symptoms associated this disease such as palsy, painful polyneuropathy, thoracoabdominal neuropathy, autonomic diabetic amyotrophy, mononeuropathy multiplex, caused motor, sensory, and dysfunction which affects peripheral nervous system, gastrointestina...