Cisplatin is an effective chemotherapeutic agent used in the treatment of a wide array of both pediatric and adult malignancies. Dose-dependent and cumulative nephrotoxicity is the major toxicity of this compound, sometimes requiring a reduction in dose or discontinuation of treatment. Recent evidence has implicated oxidative and nitrosative stress in cisplatin-induced nephrotoxicity. Aphanizom...

a new approach for analyzing cracked problems in 2d orthotropic materials using the well-known element free galerkin method and orthotropic enrichment functions is proposed. the element free galerkin method is a meshfree method which enables discontinuous problems to be modeled efficiently. in this study, element free galerkin is extrinsically enriched by the recently developed crack-tip orthot...

A new proof of Euler's formula for polytopes is presented via an approach using potential functions. In particular, a connection between Euler's formula and the Morse relation from differential topology is established.

MicroRNAs (miRNAs) are a class of ∼22 nucleotide short noncoding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding to stresses, cells either choose to restore or reprogram their gene expression patterns. This decision is partly mediated by miRNA functions, in particular by modulating the am...

Apparent shear stress acting on a vertical interface between the main channel and floodplain in a compound channel serves to quantify the momentum transfer between sub sections of this cross section. In this study, three soft computing methods are used to simulate apparent shear stress in prismatic compound channels. The Genetic Algorithm Artificial neural network (GAA), Genetic Programming (GP...

We investigate here several categories of strategic games and antagonistic situations that are known to admit potential functions, and are thus guaranteed to either possess pure Nash equilibria or to stabilize in some form of equilibrium in cases of stochastic potentials. Our goal is to indicate the generality of this method and to address its limits.