Periploca forrestii Schltr. has been used as a Chinese folk medicine due to its versatile pharmacological effects such as promoting wounds and rheumatoid arthritis. However, the antiarthritic activity of Periploca forrestii saponin (PFS) and its active compound Periplocin has still not been demonstrated. Here, we evaluated the antiarthritic effects of PFS in adjuvant-induced arthritis (AIA) rat...

The assessment of articular nociception in experimental animals is a challenge because available methods are limited and subject to investigator influence. In an attempt to solve this problem, the purpose of this study was to establish the use of dynamic weight bearing (DWB) as a new device for evaluating joint nociception in an experimental model of antigen-induced arthritis (AIA) in mice. AIA...

This paper addresses the automatic analysis of visual content and extraction of metadata beyond pure visual descriptors. Two approaches are described: Automatic Image Annotation (AIA) and Confidence Clustering (CC). AIA attempts to automatically classify images based on two binary classifiers and is designed for the consumer electronics domain. Contrastingly, the CC approach does not attempt to...

INTRODUCTION Interleukin (IL)-36 refers to three related IL-1 family cytokines, IL-36α, IL-36β, and IL-36γ, that bind to the IL-36 receptor (IL-36R). IL-36 exerts proinflammatory effects in skin and lung and stimulates T cell responses. In the present study, we examined the expression and function of IL-36R and its ligands in experimental arthritis. METHODS Collagen-induced arthritis (CIA), a...

There have been recent reviews of aspirin induced asthma (AIA), 2 the use of the COX-2 preferential inhibitor nimesulide in asthmatic patients intolerant to non-steroidal anti-inflammatory drugs (NSAIDs), and of nimesulide in general. 5 This paper discusses the importance of inhibiting prostaglandin E2 (PGE2) synthesis in AIA, and the relative safety of NSAIDs that preferentially inhibit COX-2....

We propose a concept-centered approach that combines regionand image-level analysis for automatic image annotation (AIA). At the region level, we group regions into separate concept groups and perform conceptcentered region clustering separately. The key idea is that we make use of the interand intra-concept region distribution to eliminate unreliable region clusters and identify the main regio...

Though aromatase inhibitors (AIs) are an essential part of estrogen receptor-positive (ER+) breast cancer therapy, many patients discontinue the medicine before their adjuvant therapy is completed because of the arthralgia which often accompanies the medicine. Up to half of women on AI therapy experience joint pain, and up to 20% will become non-compliant with the medicine because of the joint ...

Adjuvant-induced arthritis (AIA) is one of many animal models of rheumatoid arthritis, a disease characterized by a T-lymphocyte and macrophage cellular infiltrate. We have characterized the development of this disease model with respect to chemokine expression. Increased levels of two chemokines, RANTES, a T-lymphocyte and monocyte chemo-attractant, and KC a chemoattractant for neutrophils, we...

Few studies have investigated how well early activity measurements by accelerometers predict recovery after stroke. First, we assessed the predictive value of accelerometer-based measurements of upper-limb activity in patients with acute stroke with a hemiplegic arm. Second, we established the difference in arm activity between hospitalized stroke and nonstroke patients. In total, 129 patients ...

The objective of this study was to investigate short segment decompression of degenerative lumbar scoliosis (DLS) and the efficiency of fusion treatment.After DLS surgery, the patients were retrospectively reviewed using the VAS (visual analog scale) and ODI (Oswestry Disability Index) to assess clinical outcomes. All patients underwent posterior lumbar decompressive laminectomy, pedicle screw ...