White matter lesions (WMLs) are notable for their high prevalence and have been demonstrated to be a potential neuroimaging biomarker of early diagnosis of Alzheimer's disease. This study aimed to identify the brain functional and structural mechanisms underlying cognitive decline observed in mild WMLs. Multi-domain cognitive tests, as well as resting-state, diffusion tensor and structural imag...

Membrane fatty acid composition affects membrane structure and function. Alterations in membrane composition have been reported in old animals and it is now hypothesized that these alterations may contribute to the onset of age-related diseases. Previously, we proposed that peroxisomes might also be involved in these aging-related membrane alterations. In order to extend our previous work, we h...

Chronic obstructive pulmonary disease (COPD) is a major worldwide health problem. There exists a relationship between COPD and increased oxidative stress, and oxidants may be involved in lung damage during the course of COPD. Polymorphonuclear (PMN) cell recruitment at lung level plays an important role in free radical overproduction, impact inflammatory processes and may alter oxidant-antioxid...

Alzheimer's disease (AD) is a common aging-related neurodegenerative illness. Recently, many studies have tried to identify AD- or aging-related DNA methylation (DNAm) biomarkers from peripheral whole blood (PWB). However, the origin of PWB biomarkers is still controversial. In this study, by analyzing 2565 DNAm profiles for PWB and brain tissue, we showed that aging-related DNAm CpGs (Age-CpGs...

Generalized tonic-clonic seizures (GTCS) are characterized by unresponsiveness and convulsions, which cause complete loss of consciousness. Many recent studies have found that the ictal alterations in brain activity of the GTCS epilepsy patients are focally involved in some brain regions, including thalamus, upper brainstem, medial prefrontal cortex, posterior midbrain regions, and lateral pari...

Dysregulated metabolism is a hallmark of the aging process. Immune function tightly controlled by cellular metabolism, and emerging evidence indicates that aged immune cells have alterations in may promote aging-related disease. Lifestyle interventions including diet exercise are potent strategies for targeting metabolic dysfunction aging, but to date, only few studies examined ability or regul...

Background: Suffering from tinnitus causes mental distress in most patients. Recent findings point toward a diminished activity of the brain's default-mode network (DMN) in subjects with mental disorders including depression or anxiety and also recently in subjects with tinnitus-related distress. We recently developed a therapeutic intervention, namely the Heidelberg Neuro-Music Therapy (HNMT),...

OBJECTIVE The present study investigated resting fMRI connectivity within the default mode (DMN), salience (SN), and central executive (CEN) networks in relation to neurocognitive performance and symptom severity in trauma-exposed patients with major depressive disorder (MDD). METHOD Group independent component analysis was conducted among patients with MDD (n = 21), examining DMN, SN, and CE...