Tris(2-aminobenzimidazole) conjugates with antisense oligonucleotides are effective site-specific RNA cleavers. Their mechanism of action is independent of metal ions. Here we investigate conjugates with peptide nucleic acids (PNA). RNA degradation occurs with similar rates and substrate specificities as in experiments with DNA conjugates we performed earlier. Although aggregation phenomena are...

We describe a bottom-up chart realization algorithm adapted for use with Combinatory Categorial Grammar (CCG), and show how it can be used to efficiently realize a wide range of coordination phenomena, including argument cluster coordination and gapping. The algorithm has been implemented as an extension to the OpenNLP open source CCG parser. As an avenue for future exploration, we also suggest...

Introduction In recent times there has been an increase in the availability of and requirement for public domain data that can be used to construct community level profiles in order to study contextual level phenomena. In this paper, we will review the developments that have given rise to this requirement, and explain how we have constructed a database of community characteristics at a postcode...

Electrostatic interactions play an important role in numerous self-assembly phenomena, including colloidal aggregation. Although colloids typically have a dielectric constant that differs from the surrounding solvent, the effective interactions that arise from inhomogeneous polarization charge distributions are generally neglected in theoretical and computational studies. We introduce an effici...

We calculate the scaling behavior of the second-kind self-similar blow-up solution of an aggregation equation in odd dimensions. This solution describes the radially symmetric finite-time blowup phenomena and has been observed in numerical simulations of the dynamic problem. The nonlocal equation for the self-similar profile is transformed into a system of ODEs that is solved using a shooting m...

In this study we report efficient method for the syntheses of mono- and diarylated diphenyldithienylethene (DPDTE) via a palladium-catalyzed C–H arylation reaction. These new derivatives showed amplified luminescent properties thanks to change in polarity, particularly presence an electron-withdrawing groups (EWG). Moreover, arylated DPDTEs dual-emissive phenomena, including fluorescence organi...

Irreversible aggregation and annihilation processes occur in many natural phenomena [1,2]. The kinetics of each of these processes is well understood both on the mean-field level which provides an accurate description when fluctuations in reactant densities can be ignored [3,1,4] and in the fluctuation-dominated regime which occurs in low-dimensional systems, see [5], and references therein. It...