We have developed a new method of crosstalk correction in simultaneous dual-isotope imaging with Tl-201 and I-123 by using crosstalk ratios and a blurring filter. Single isotope myocardial studies (10 for Tl-201 and 7 for I-123) were performed with a dual energy window acquisition mode and two low energy general-purpose collimators. Then two planar images acquired with dual energy windows for a...

(1 + 1) [1636, 1637, 2320, 2205]. (1 + ) [1067]. (1 + λ) [2458]. (2− c 1 √ N ) [1357]. (2t+ 1) [799]. (k − 1) [1177]. (s, t) [446]. 0 [2383, 895]. {0, 12} [1473]. 1 [2383, 1599, 2287, 895, 2076, 1155, 1088, 2435, 2200, 1951, 2394, 1536, 1873, 260, 1451]. 1 + φ [1931]. 11/6 [280]. 13/9 [1451]. 2 [1763, 1277, 2086, 2028, 2196, 1997, 332, 1019, 474, 237, 2088, 1765, 2390, 414, 1909, 2401, 260, 240...

BACKGROUND Four cardiac hormones i.e. atrial natriuretic peptide (ANP), vessel dilator, long acting natriuretic peptide (LANP) and kaliuretic peptide have anticancer effects in vitro. MATERIALS AND METHODS These four cardiac hormones were infused subcutaneously for 28 days with weekly fresh hormones at 3 nM min(-1) kg(-1) body weight in athymic mice bearing human breast adenocarcinomas. RES...

OBJECTIVE To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation. METHODS A muscle crush injury and 40% estimated blood volume controlled hemorrhage was completed in 24 Yucatan mini-pigs. Pigs were untreated or resuscitated with HBOC-201 or 6% hetastarch (HEX) at 20 min. Invasive hemodynamics and cli...

PURPOSE INGN 201 (Ad-p53) is a replication-defective adenoviral vector that encodes a wild-type p53 gene driven by the cytomegalovirus promoter. INGN 201 has been shown to have antitumoral activity against human prostate cancer cell lines. This study was undertaken to determine the safety of INGN 201 in patients with locally advanced prostate cancer, to assess transgene expression, and to evalu...

It is suggested that sublingual nitroglycerine can improve the ability of T1-201 for detection of viable myocardium. Methods and Results: In a randomized, double blind study, 50 patients who had fixed defects on stress-redistribution scan, were randomized into two groups. In group I, patients received 0.4-0.8 mg sublingual nitroglycerine, before T1-201 reinjection. In group II, reinjectio...

OBJECTIVES Cerebral ischemia can occur during cardiopulmonary bypass, especially during low flow. HBOC-201 (OPK Biotech, Cambridge, Mass) is a hemoglobin-based oxygen-carrying solution that enhances oxygen delivery. This project evaluated the benefits on total body and cerebral oxygen delivery and consumption using HBOC-201 during cardiopulmonary bypass. METHODS Twelve immature swine were ass...

PURPOSE The aim of this study was to assess whether migration of thallium-201 ((201)Tl) to the olfactory bulb were reduced in patients with olfactory impairments in comparison to healthy volunteers after nasal administration of (201)Tl. PROCEDURES 10 healthy volunteers and 21 patients enrolled in the study (19 males and 12 females; 26-71 years old). The causes of olfactory dysfunction in the ...