The group of AGC protein kinases includes more than 60 protein kinases in the human genome (e.g. PDK1 and isoforms of PKA, PKC, PRK, PKB/Akt, S6K, SGK, RSK, MSK, ROCK, GRK, amongst others). This group is also widely represented in other eukaryotes, including organisms that cause human infectious diseases. Human AGC kinases are involved in diverse cellular functions and are potential targets for...

In the early years of radio circuits, fading (defined as slow variations in the amplitude of the received signals) required continuing adjustments in the receiver's gain in order to maintain a relative constant output signal. Such situation led to the design of circuits, which primary ideal function was to maintain a constant signal level at the output, regardless of the signal's variations at ...

The identification of PDK1 as a kinase that phosphorylates the AGC family of kinases led to a hunt for 'PDK2', a hypothetical regulated kinase(s) that would be required for full activation of the AGC kinases. Recent findings suggest that the elusive PDK2 may actually be a familiar kinase with an atypical associate.

Oral delivery systems for bioactive materials have long been of interest in food applications due to their contribution to the functional and sensory properties. Amylose complexes with hydrophobic molecules can be used as a delivery system to the intestine having the advantages of being readily available, cheap, nontoxic and biodegradable. In this study genistein, a major soy isoflavone possess...

Phosphorylation on the activation loop of AGC kinases is typically mediated by PDK1. The precise mechanism for this in-trans phosphorylation is unknown; however, docking of a hydrophobic (HF) motif in the C-tail of the substrate kinase onto the N-lobe of PDK1 is likely an essential step. Using a peptide array of PKA to identify other PDK1-interacting sites, we discovered a second AGC-conserved ...

Abstract The objective of this work was to apply the random forest (RF) algorithm modelling aboveground carbon (AGC) stock a tropical by testing three feature selection procedures – recursive removal and uniobjective multiobjective genetic algorithms (GAs). used database covered 1,007 plots sampled in Rio Grande watershed, state Minas Gerais state, Brazil, 114 environmental variables (climatic,...

To improve the performance and economy of hybrid energy storage system (HESS) coordinating thermal generators to participate in automatic generation control (AGC), a HESS bi-layer capacity configuration model that considers strategy net benefits is proposed. In addition, an improved mode-pursuing sampling (MPS) optimization algorithm based on meta-model presented accuracy solving. lower layer, ...

This paper addresses an integral sliding mode control approach for automatic generation control (AGC) of a single area power system. Genetic algorithm (GA) is employed to search the parameters of the sliding surface. The proposed design is investigated for AGC of a single area power system, made up of reheated thermal and gas power generations. Compared with the GA-based proportion-integral (PI...

The Apollo Guidance Computer (AGC) is an engineering marvel. AGC performed all of the necessary computation to successfully guide, navigate, and control spacecraft, which carried Neil Armstrong Buzz Aldrin surface moon back in 1969 as part 11 mission. Weighing at a staggering 32 kg featuring blazing-fast 2.048-MHz clock, it was first computer use silicon integrated circuits (ICs). Mankind has m...