نتایج جستجو برای: afnor p18

تعداد نتایج: 1067  

Journal: :Hepatology 2005

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Journal: :Indian Journal of Rheumatology 2009

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Journal: :Journal of Pain and Symptom Management 2012

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2012
Jordan Pascoe Douglas Hollern Rachel Stamateris Munira Abbasi Lia C. Romano Baobo Zou Christopher P. O’Donnell Adolfo Garcia-Ocana Laura C. Alonso

Pancreatic β-cell proliferation is infrequent in adult humans and is not increased in type 2 diabetes despite obesity and insulin resistance, suggesting the existence of inhibitory factors. Free fatty acids (FFAs) may influence proliferation. In order to test whether FFAs restrict β-cell proliferation in vivo, mice were intravenously infused with saline, Liposyn II, glucose, or both, continuous...

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Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Douglas S Kim Glenda J Froelick Richard D Palmiter

The dynamics of dopamine receptor signaling efficacy were characterized in developing mice by measuring striatal c-Fos expression after dopaminergic agonist treatment at postnatal day 4 (P4) to P18. Control mice and mutant mice, in which dopamine production is inactivated in dopaminergic neurons by gene targeting, were treated with saline; a synthetic dopamine precursor, L-3,4-dihydroxyphenylal...

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2006
Hui Yu Youzhong Yuan Hongmei Shen Tao Cheng

Transplantation-associated stress can compromise the hematopoietic potential of hematopoietic stem cells (HSCs). As a consequence, HSCs may undergo “exhaustion” in serial transplant recipients, for which the cellular and molecular bases are not well understood. Hematopoietic exhaustion appears to be accelerated in the absence of p21Cip1/Waf1 (p21), a cyclindependent kinase inhibitor (CKI) in ir...

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Journal: :Genes & development 2005
Tamar Uziel Frederique Zindy Suqing Xie Youngsoo Lee Antoine Forget Susan Magdaleno Jerold E Rehg Christopher Calabrese David Solecki Charles G Eberhart Sarah E Sherr Sarah Plimmer Steven C Clifford Mary E Hatten Peter J McKinnon Richard J Gilbertson Tom Curran Charles J Sherr Martine F Roussel

Recurrent genetic alterations in human medulloblastoma (MB) include mutations in the sonic hedgehog (SHH) signaling pathway and TP53 inactivation (approximately 25% and 10% of cases, respectively). However, mouse models of MB, regardless of their initiating lesions, generally depend upon p53 inactivation for rapid onset and high penetrance. The gene encoding the cyclin-dependent kinase inhibito...

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Journal: :The American journal of physiology 1998
Timothy J Kowalski Andrea M Ster Gerard P Smith

The ontogeny of hyperphagic behavior in the Zucker fatty ( fa/ fa) rat was examined. Wild-type, +/ fa, and fa/ fapups aged postnatal day 5( P5), P9, P12, P15, and P18 were evaluated using a test that measured ingestive behavior independent of the dam. The independent ingestive test consisted of giving pups access to a test solution [half-and-half (cream and milk)] on a tissue on the floor of a ...

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Journal: :Cancer research 2014
Feng Bai Ho Lam Chan Alexandria Scott Matthew D Smith Cheng Fan Jason I Herschkowitz Charles M Perou Alan S Livingstone David J Robbins Anthony J Capobianco Xin-Hai Pei

BRCA1 mutation carriers are predisposed to developing basal-like breast cancers with high metastasis and poor prognosis. Yet, how BRCA1 suppresses formation of basal-like breast cancers is still obscure. Deletion of p18(Ink4c) (p18), an inhibitor of CDK4 and CDK6, functionally inactivates the RB pathway, stimulates mammary luminal stem cell (LSC) proliferation, and leads to spontaneous luminal ...

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2015
Louise Kime Helen A. Vincent Deena M. A. Gendoo Stefanie S. Jourdan Colin W. G. Fishwick Anastasia J. Callaghan Kenneth J. McDowall

In the Supplementary Information file originally published with this Article, the chemical structures of P16 and P18 were truncated in Supplementary Table S1. These errors have been corrected in the Supplementary Information that now accompanies the Article.

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