BACKGROUND Aflatoxins (AFs) are secondary hazardous fungal metabolites that are produced by strains of some Aspergillus species on food and feedstuffs. Aflatoxin B1 (AFB1) is one of the most important AF with high toxicity. Prevention of AF production and their elimination from food products is a matter of importance for many researchers in the last decades. Nanomaterials applications in medica...

It was postulated that a population in sub-Saharan Africa, known to be at high risk for aflatoxicosis due to frequent ingestion of aflatoxin (AF)-contaminated foods could also be exposed to polycyclic aromatic hydrocarbons (PAHs) from a variety of environmental sources. Previously, participants in this population were shown to be highly exposed to AFs, and this exposure was significantly reduce...

The effects of feeding clinoptilolite on hematology, performance, and health of newborn Balouchi lambs were evaluated in this experiment. In a completely randomized design, 30 newborn lambs were allocated to three groups and fed by basal diet (C0; without clinoptilolite) and C1 and C2 (the basal diet plus 1.5% and 3% clinoptilolite, respectively, for 6 weeks (3 weeks before and 3 weeks after we...

background : aflatoxins (afs) are secondary hazardous fungal metabolites that are produced by strains of some aspergillus species on food and feedstuffs. aflatoxin b 1 (afb 1 ) is one of the most important af with high toxicity. prevention of af production and their elimination from food products is a matter of importance for many researchers in the last decades. nanomaterials applications in m...

Aflatoxin-producing fungi contaminate food and feed during pre-harvest, storage and processing periods. Once consumed, aflatoxins (AFs) accumulate in tissues, causing illnesses in animals and humans. Most human exposure to AF seems to be a result of consumption of contaminated plant and animal products. The policy of blending and dilution of grain containing higher levels of aflatoxins with unc...

Mycotoxin contamination of feed ingredients impart considerable economic costs stemming from cost of preventative and mitigation practices, reduced value of contaminated feeds, contamination of foods of animal origin and reduction in animal performance and health. Therefore, much research has sought to find methods to overcome these issues. Currently, the best procedure is to minimize mycotoxin...

Food and feed contamination by aflatoxin (AF)B₁ has adverse economic and health consequences. AFB₁ degradation by microorganisms or microbial enzymes provides a promising preventive measure. To this end, the present study tested 43 bacterial isolates collected from maize, rice, and soil samples for AFB₁-reducing activity. The higher activity was detected in isolate L7, which was identified as B...

Monoclonal antibodies specific for aflatoxin B1, aflatoxin B2, aflatoxin M1, and the major aflatoxin-DNA adducts were obtained following fusion of mouse SP-2 myeloma cells with spleen cells of mice immunized with aflatoxin B1 covalently bound to bovine gamma globulin. The aflatoxin-modified protein used to immunize mice was produced chemically by activating aflatoxin B1 to a 2,3-epoxide derivat...

AFLATOXIN B1, a carcinogenic metabolite of the fungus Aspergillus flavus, is acutely toxic to a number of species, including rats. Male rats (LD50 7-2 mg./kg.) are more susceptible to the acute oral effects of aflatoxin than are females (LD50 17.9 mg./kg.) (Butler, 1964). Aflatoxin B1 is metabolised to aflatoxin M1 which is present in the blood and urine of dosed rats (Butler and Clifford, 1965...

Seeds of aflatoxin-resistant and aflatoxin-susceptible maize lines were inoculated with conidia of aflatoxin-producing Aspergillus flavus or A. parasiticus isolates or isogenic non-producing mutants. Conidia were recovered from resistant maize seed after seven days in significantly lower amounts for aflatoxin-producing A. flavus and A. parasiticus strains than for isogenic mutants incapable of ...