OBJECTIVE To compare the difference in effect on pregnant women and fetuses between very advanced maternal age (age of or over 45 years) other ages below years). STUDY DESIGN A descriptive study. PLACE AND DURATION OF Changyi People's Hospital, China, from June 2017 September 2020. METHODOLOGY Four-hundred singleton pregnancies were selected. One hundred three at years (Group A) 297 B) grouped ...

A retrospective review of medical records of 80 children with thyroid dysgenesis (TD) was conducted to determine the association of gender and maternal age with TD. The study subjects were attending the Pediatric Endocrinology Clinic of our hospital which is a large tertiary care Multispecialty Pediatric Center located in Chandigarh, Northwest India. There were no gender differences (boys to gi...

OBJECTIVE To investigate outcomes of twin gestations with advanced maternal age (AMA). STUDY DESIGN Historical cohort of twin gestations cared for by a maternal-fetal medicine faculty practice. Outcomes of patients with AMA (70) and non-AMA (75) were compared. AMA was defined as age > or =35. Analysis including mode of delivery, gestational age at delivery and overall complications was perfor...

Nucleotide repeat instability is associated with an increasing number of cancers and neurological disorders. The mechanisms that govern repeat instability in these biological disorders are not well understood. To examine genetic aspects of repeat instability we have introduced an expanded CAG trinucleotide repeat into transgenic mice. We have detected intergenerational CAG repeat instability in...

OBJECTIVE To examine the association between maternal age and a wide range of adverse pregnancy outcomes after adjustment for confounding factors in obstetric history and maternal characteristics. METHODS This was a retrospective study in women with singleton pregnancies attending the first routine hospital visit at 11 + 0 to 13 + 6 weeks' gestation. Data on maternal characteristics, and medi...