Background: It is assumed that adult stem/progenitor cells are responsible for cycling remodeling of the uterus endometrium throughout the reproductive life of the female. This study aimed to identify and localize stem/progenitor cells in the mice uterus using immunohistochemistry. Materials and Methods: 6-8 weeks old virgin female NMRI mice were submitted to the vaginal smear examination to de...

Objective(s): In some previous studies, the extract of embryonic carcinoma cells (ECCs) and embryonic stem cells (ESCs) have been used to reprogram somatic cells to more dedifferentiated state. The aim of this study was to investigate the effect of mouse ESCs extract on the expression of some pluripotency markers in human adipose tissue-derived stem cells (ADSCs). Materials and Methods: Human A...

Background: The recent improvements in wound healing have led to new strategies in regenerative medicine. Burn wound healing is an important issue in skin regeneration and has multiple indications for stem cell therapy. Hair follicle stem cells (HFSCs) are a highly promising source of stem cells for healing use, as these cells are accessible, active and pluripotent adult stem cells. Methods: HF...

background: during the resent years there has been interest in using bone marrow stem cells to treat liver cirrhosis. however, there is a potential concern for malignant transformation after stem cell therapy. the aim of this study was to evaluate the development of hepatocellular carcinoma (hcc) after autologous bone marrow stem cell transplantation for liver cirrhosis. methods: all the patien...

introduction: during the last decade, advances in tissue engineering and stem cell-based tooth regeneration have provided realistic and attractive means of replacing lost or damaged teeth. the first adult stem cells isolated from dental tissues were dental pulp stem cells (dpscs). when transplanted with hydroxyl apatite/tri calcium phosphate (ha/tcp) powder, they formed a dentin-like structure ...

the aim of this study was to isolate mouse embryonic stem cells from late blastocyst stage embryos and to use them as a model system for the study of hematopoietic induction outside the embryo by coculturing of embryonic stem cells with bone marrow stromal cells. blastocyst stage embryos from pregnant nmri mice were obtained and cultured for 1-2 days in dmem medium. the inner cell masses formed...

neural stem cells (nscs) as a heterogeneous multipotent and self- renewal population are found in different areas in the developing mammalian nervous system, as well as the sub-ventricular zone (svz) and the hippocampus of the adult brain. nscs can give rise to neurons, astrocytes and oligodendrocytes. the aim of this study was to differentiate neural stem cells into noradrenergic–like cells in...