نتایج جستجو برای: adrenergic receptors adrb3

تعداد نتایج: 256242  

Journal: :The Journal of pharmacology and experimental therapeutics 2016
Shahrooz Nasrollahi-Shirazi Sonja Sucic Qiong Yang Michael Freissmuth Christian Nanoff

Blockage of β1-adrenergic receptors is one of the most effective treatments in cardiovascular medicine. Esmolol was introduced some three decades ago as a short-acting β1-selective antagonist. Landiolol is a more recent addition. Here we compared the two compounds for their selectivity for β1-adrenergic receptors over β2-adrenergic receptors, partial agonistic activity, signaling bias, and phar...

Journal: :Investigative ophthalmology & visual science 1977
A H Neufeld E D Page

Alpha- and beta-adrenergic receptors were studied by measuring the binding of 3H-dihydroergocryptine and 3H-dihydroalprenolol, respectively, to membranes prepared from homogenized rabbit iris--ciliary bodies. The binding of 3H-dihydroergocryptine appears to be specific for alpha-adrenergic receptors, since adrenergic agents displace this radioligand with the following order of potency: phentola...

Journal: :The Biochemical journal 2013
Yuanjun Wu Yu Zhao Xiaojie Ma Yunjuan Zhu Jaimin Patel Zhongzhen Nie

AGAP2 [Arf (ADP-ribosylation factor) GAP (GTPase-activating protein) with GTP-binding-protein-like, ankyrin repeat and PH (pleckstrin homology) domains] is a multidomain Arf GAP that was shown to promote the fast recycling of transferrin receptors. In the present study we tested the hypothesis that AGAP2 regulates the trafficking of β2-adrenergic receptors. We found that AGAP2 formed a complex ...

2005
Tarcisio Vago Maurizio Bevilacqua Guido Norbiato Gabriella Baldi E. Chebat Pierluigi Bertora Giorgio Baroldi Roberto Accinni

Discontinuous density sucrose gradient centrifugation was used to isolate membrane vesicles from the left ventricle of three normal subjects (one prospective organ donor and two traffic victims whose hearts were obtained 1 hour after death) and nine patients undergoing cardiac transplantation as a consequence of idiopathic dilated cardiomyopathy. Sarcolemma-enriched subcellular fractions, detec...

Journal: :Hypertension 1984
M G Caron L M Leeb-Lundberg C D Strader K E Dickinson V M Pickel T Joh R J Lefkowitz

Recent developments in the characterization of the adrenergic receptors have led to the identification and purification of the binding subunits of the various catecholamine receptors. beta-Adrenergic receptors have been identified in a wide variety of tissues by photoaffinity labeling with the antagonist [125I]p-azidobenzylcrazolol and have been purified to apparent homogeneity from several of ...

2001
Robert J. Lefkowitz

The adenylate cyclase-coupled &-adrenergic receptor of the frog erythrocyte has served as a useful model system for elucidating the mechanisms of catecholamine-induced desensitization. In this system, it has been previously demonstrated that agonist-induced refractoriness is associated with sequestration of the @adrenergic receptors in vesicles away from the cell surface and from their effector...

Journal: :Investigative ophthalmology & visual science 2005
Amalia Enríquez de Salamanca Karyn F Siemasko Yolanda Diebold Margarita Calonge Jianping Gao Mónica Juárez-Campo Michael E Stern

PURPOSE To study the presence of muscarinic and alpha- and beta-adrenergic receptors in a normal human conjunctival epithelial (IOBA-NHC) cell line. METHODS Neurotransmitter receptors were determined in IOBA-NHC cells by flow cytometry, immunofluorescence, and Western blot analysis. Antibodies to M(1)-, M(2)-, and M(3)-muscarinic and to alpha(1A)-, alpha(1B)-, alpha(1D)-, alpha(2A)-, alpha(2B...

Journal: :Cardiovascular research 2004
Liza Barki-Harrington Cinzia Perrino Howard A Rockman

Adrenergic receptors play a pivotal role in regulating cardiac function in response to a constantly changing environment. Altered alpha and beta adrenergic receptor signaling in vivo is associated with cardiac hypertrophy and failure. This review focuses on the different roles of adrenergic receptors in regulating cardiac function under normal and pathological conditions. Understanding the sign...

Journal: :Molecular pharmacology 2017
Adrian P Campbell Laurence P G Wakelin William A Denny Angela M Finch

The α1-adrenergic receptors are targets for a number of cardiovascular and central nervous system conditions, but the current drugs for these receptors lack specificity to be of optimal clinical value. Allosteric modulators offer an alternative mechanism of action to traditional α1-adrenergic ligands, yet there is little information describing this drug class at the α1-adrenergic receptors. We ...

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