Using a highly sensitive quantitative RT-PCR method for the measurement of CYP11B1 (11beta-hydroxylase) and CYP11B2 (aldosterone synthase) mRNAs, we previously demonstrated that CYP11B2 expression in the central nervous system (CNS) is subject to regulation by dietary sodium. We have now quantified the expression of these genes in the CNS of male Wistar Kyoto (WKY) rats in response to systemic ...

In China, the ethylacetate extract of the herb Tripterygium wilfordii Hook f (TWEE), containing the major active ingredient triptolide, is often used with favorable effect on rheumatoid arthritis patients, in alternation with the use of prednisone. The mechanism of this therapeutic effect, however, has not been completely delineated. In this study, we studied how TWEE and prednisone affect the ...

One of the early theories in regard to the function of the adrenal gland was that it acted as a detoxifying agent (1, a). While no convindng proof of this hypothesis was presented, many scattered facts have been brought out which show that the adrenals are involved in the reaction of the organism to infection and intoxication, and which suggest that these glands play an important r61e in the pr...

The adrenal cortex undergoes remodeling during fetal and postnatal life. How zona reticularis emerges in the postnatal gland to support adrenarche, a process whereby higher primates increase prepubertal androgen secretion, is unknown. Using cell-fate mapping and gene deletion studies in mice, we show that activation of PKA has no effect on the fetal cortex, while it accelerates regeneration of ...

Adrenal myelolipoma is a rare benign tumor that is composed of hematopoietic cells and mature fat. Mostly, these nonfunctioning tumors are distinguished incidentally during autopsy or radiologic investigations. Here, we report a case of 46-year-old man presented with nonspecific abdominal pain for one year, who had right adrenal mass with fat density detected by radiologic investigation. Histop...

A relationship between pantothenic acid and the adrenal gland has been evident since the earliest work with this vitamin was done. Morgan and Simms (1) found pathologic changes in the adrenals of rats on diets free from “filtrate factor,” and reported (2) that the achromotrichia of rats maintained on these diets could be at least partly reversed by extracts of the thyroid and of the adrenal cor...

Pheochromocytomas can be a part of familial neoplastic syndromes, in which case they tend to be multiple and involve both adrenal glands. Therefore, sparing adrenocortical function represents a major concern while dealing with these hereditary lesions. Herein, we describe the clinical characteristics and the management strategy of a patient with von Hippel-Lindau (VHL) disease who had multiple,...

background inferior turbinate hypertrophy (ith) is one of the common causes of nasal obstruction. in some case with ith due to allergic rhinitis medical therapy can be useful and in cases with refractory ith surgical techniques may be helpful. although there is no excellence [or superiority] among these surgical methods, radiofrequency (rf) has recently become popular. objectives this study com...

adrenal gland pseudocysts are not common conditions, and most of them are nonfunctional and asymptomatic. however, large pseudocysts may causes abdominal discomfort and have compressive effects on adjacent organs. they may rupture spontaneously or after trauma, and lead to retroperitoneal hemorrhage and surgical emergency. herein, we report a case of 21-year-old female who presented with acute ...