The aim of this study was to evaluate the association between Pediatric Asthma Quality of Life Questionnaire (PAQLQ) and Asthma Control Test (ACT) in patients with poor asthma control. Children between 7-17 years of age with diagnosis of persistent asthma who are not on daily inhaler corticosteroid therapy were involved. At enrollment, sociodemographic and asthmatic characteristics were investi...

INTRODUCTION Symptomatic adrenal adenoma usually presents with systemic symptoms. Depending on the function of the adenoma, the patient can present with pheochromocytoma-like symptoms; primary hyperaldosteronism and Cushing syndrome (weight gain, weakness, depression, and bruising). CASE REPORT A 41 year-old lady presented with multiple metatarsal and phalangeal fractures of the both feet wit...

Results. Gravimetric and variance analysis demonstrated the most remarkable decrease of the adrenal gland weight after the application of 75.0 mg/kg/bw MPA (from 35.66 ± 11.78 to 13.41 ± 8.41 mg (p<0.001). On the other hand, morphometric analysis demonstrated that adrenal cortex volume was the most significantly reduced from 11.30 ± 3.53 in the control group to 2.04 ± 0.90 mm3 in the group trea...

Pheochromocytomas can be a part of familial neoplastic syndromes, in which case they tend to be multiple and involve both adrenal glands. Therefore, sparing adrenocortical function represents a major concern while dealing with these hereditary lesions. Herein, we describe the clinical characteristics and the management strategy of a patient with von Hippel-Lindau (VHL) disease who had multiple,...

Cholesterol and ascorbic acid of adrenals are significantly diminished in scorbutic guinea pigs (1). As these substances appear to be related to the formation of adrenal cortical hormone (a), it has been indicated that the secretion of this hormone might diminish in scurvy. The urinary excretion of 17-ketosteroids in females is said to depend almost entirely on the activity of the adrenal corte...

The lineage relationships of fetal adrenal cells and adrenal capsular cells to the differentiated adrenal cortex are not fully understood. Existing data support a role for each cell type as a progenitor for cells of the adult cortex. This report reveals that subsets of capsular cells are descendants of fetal adrenocortical cells that once expressed Nr5a1. These fetal adrenocortical cell descend...

The relation of adrenal function to hypertension in man is discussed. It is pointed out that hypertension accompanying hyperaldosteronism may recur after removal of the tumor and correction of the electrolyte abnormality. The complex relationship between blood pressure, excretion of sodium loads, total body sodium and aldosterone excretion is emphasized. Results following bilateral adrenalectom...

The adrenal gland is composed of two ontogenetically and functionally distinct t issues, the medulla and the cortex. The cortex, the subject of the present art icle, forms the major part of the murine gland and is further organized into three concentric layers: the outer zona glomerulosa, the zona fasciculata and the innermost X-zone. Specific hormonal production is finely tuned in t ime and sp...

Presumptive evidence for the production of steroids by the human fetal adrenal gland has accumulated during recent years. The studies involved mostly analysis of fetal adrenal tissue (14) or umbilical cord blood (5-8) for steroid content, the results of which did not unequivocally establish steroid synthesis by the fetal adrenal cortex. Lanman and Silverman (9) demonstrated the conversion of pr...

The relation of adrenal function to hypertension in man is discussed. It is pointed out that hypertension accompanying hyperaldosteronism may recur after removal of the tumor and correction of the electrolyte abnormality. The complex relationship between blood pressure, excretion of sodium loads, total body sodium and aldosterone excretion is emphasized. Results following bilateral adrenalectom...