BACKGROUND Historically, treatment of confirmed primary aldosteronism has been adrenalectomy for unilateral adenoma; bilateral hypersecretion is treated medically. Increasingly, we use adrenal venous sampling (AVS) to define unilateral hypersecretion. Histology of glands resected based on AVS often reveals multiple nodules or hyperplasia. The aim of this study was to compare patients with multi...

Before surgery for primary aldosteronism (PA), localization is evaluated with adrenal vein sampling (AVS). A 56-year-old Japanese woman had a right adrenal mass, hypokalemia, and a high aldosterone/renin ratio. Stress tests confirmed the diagnosis of PA. Subsequently, preoperative AVS was performed and right adrenal hemorrhage (AH) occurred unexpectedly. Because hypertension persisted, laparosc...

Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats throughout their lifespan starting at 5 weeks. Their mean survival times were 89 to 105 weeks of age. The total tumor incidences were 70 to 76.7% and 87 to 95.8% in males and females, respectively. The common neoplasmas were pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular Leydig cell tumor in ma...

Cushing's syndrome (CS) during pregnancy is a rare condition with significant maternal and fetal complications. A case of CS during the third trimester of pregnancy secondary to adrenocortical adenoma was reported. Literature review revealed the disadvantages of different treatments in this period. Besides the conservative treatment, surgery is recommended for CS during the third trimester of p...

PURPOSE The indication for laparoscopic total or partial adrenalectomy in patients with aldosterone producing adrenal adenoma remains controversial. We compared retroperitoneoscopic partial and total adrenalectomy for aldosterone producing adrenal adenoma in a prospective, randomized, multicenter trial. MATERIALS AND METHODS Patients with aldosterone producing adrenal adenoma were randomized ...

Dysregulation of aldosterone or cortisol production can predispose to hypertension, as seen in aldosterone-producing adenoma, a form of primary aldosteronism. We investigated the role of microRNA (miRNA) in their production, with particular emphasis on the CYP11B1 (11β-hydroxylase) and CYP11B2 (aldosterone synthase) genes, which produce the enzymes responsible for the final stages of cortisol a...

Adrenal collision tumors (ACTs) refer to coexistence of two adjacent, but histologically distinct neoplasms involving the adrenal gland without histologic admixture at interface. ACTs include adenoma with myelolipoma, adenoma with metastases, hemangioma with adenoma, and adrenocortical carcinoma with myelolipoma. In addition, hemorrhage into a pre-existing adrenal mass can mimic an ACT, and it ...

ADRENAL-SPECIFIC RADIOLIGAND, 131I-6β-iodomethyl-19norcholest-5(10)-en-3β-ol (131I-adosterol)1 was developed in the 1970s. Increased uptake of the agent in tumor regardless of visualization of the contralateral gland suggests that the adrenal mass is usually a benign cortical adenoma.2 This agent has the potency to diagnose lesions of the adrenal cortex and has been widely used to diagnose lesi...

Adrenal rest tumor in liver is a very rare tumor. It originates from an adrenal rest, which is derived from the aberrant adrenocortical tissue. Adrenal rest tumor is an ectopic collection of adrenocortical cells in extra-adrenal sites. This tumor may be hormonally active and manifest endocrine syndromes. But, most tumors are non-functioning and benign. Histologically, hepatic adrenal rest tumor...

MOTS CLÉS Hypertension artérielle secondaire ; Anévrisme artériel rénal ; Adénome de Conn ; A 58-year-old woman presented with resistant hypertension and hypokalaemia. Biological primary hyperaldosteronism was detected: aldosterone to renin ratio, 37.5; 24-hour urine aldosterone excretion, 25 g. Computed tomography (Fig. 1) diagnosed a right adrenal adenoma (26mm diameter) coexisting with a hom...