INTRODUCTION Primary hyperaldosteronism is only rarely caused by unilateral adrenal hyperplasia. CASE PRESENTATION A 73-year-old hypertensive Greek man (on 10 mg amlodipine for the last ten years) presented in the emergency department with severe muscle weakness of all limbs. The initial physical and laboratory examination revealed normal blood pressure, muscle weakness, severe hypokalemia, s...

BACKGROUND There is a major lack of randomized controlled trials (RCTs) evaluating the effects of hydrocortisone (HC) substitution therapy in patients with secondary adrenal insufficiency. Therefore, we evaluated the effects of two different replacement doses of HC on health-related quality of life (HRQoL) in a RCT. METHODS This RCT with a double-blind cross-over design was performed at the U...

Background: For preclinical evaluations of radiopharmaceuticals, most studies are carried out on mice. Values of electron specific absorbed fractions (SAF) have had vital role in the assessment of absorbed dose. In past studies, electron specific absorbed fractions were given for limited source target pairs using older reports of human organ compositions.Objective: Electron specific absorbed fr...

Background: Annual patient effective dose equivalent can be considered as a quantitative physical parameter describing the activities performed in each nuclear medicine department. Annual staff dose equivalent could be also considered as a parameter describing the amount of radiation risk for performing the activities. We calculated the staff to patient dose equivalent ratio to be used as a phy...

Abstract Introduction Adrenal myelolipomas (AMs) are rare, benign tumors without endocrine activity comprised of mature adipose and hematopoietic tissue. Surgical excision may be required for lesions which have associated symptoms, those that growing, or features concerning malignancy. Congenital adrenal hyperplasia (CAH) is often with masses such as AM. The majority literature regarding AMs co...

background: most preclinical studies are carried out on mice. for internal dose  assessment of a mouse, specific absorbed fraction (saf) values play an important role.  in most studies, saf values are estimated using older standard human organ compositions  and values for limited source target pairs. objective: saf values for monoenergetic photons of energies 15, 50, 100, 500,  1000 and 4000 ke...

Purpose The adrenal glands are a common site of metastases because of their rich blood supply. Previously, adrenal metastases were treated with systemic chemotherapy or, more rarely, with surgical resection or palliative radiation therapy. Stereotactic body radiation therapy (SBRT) has recently emerged as an attractive noninvasive approach to definitively treat these lesions. We present our exp...

Background: Adrenal insufficiency is frequently neglected and underappreciated, potentially severe complication of systemic glucocorticoid therapy. Objectives: We aimed to evaluate the prevalence induced adrenal in giant cell arteritis (GCA). Methods: analysed function data a cohort GCA patients diagnosed between July 2014 2019, whom discontinuation methylprednisolone therapy was planned. teste...

OBJECTIVE To assess the performance of current clinical recommendations for the evaluation of an adrenal incidentaloma. DESIGN AND METHODS LITERATURE REVIEW: Electronic databases (Pubmed, Ovid and citation searches from key articles) from 1980 to 2008 were searched. Eligible studies were those deemed most applicable to the clinical scenario of a patient referred to an endocrinologist for assess...

BACKGROUND Glucocorticoid replacement is commonly required to treat secondary adrenal insufficiency after surgical resection of unilateral cortisol-secreting adrenocortical adenomas. Here, we describe a patient with unilateral cortisol-secreting adenomas in which the preoperative use of mifepristone therapy was associated with recovery of the hypothalamic-pituitary-adrenal (HPA) axis, eliminati...