نتایج جستجو برای: admixture compatibility

تعداد نتایج: 31935  

Journal: :Molecular ecology 2014
J Monzón R Kays D E Dykhuizen

The evolutionary importance of hybridization as a source of new adaptive genetic variation is rapidly gaining recognition. Hybridization between coyotes and wolves may have introduced adaptive alleles into the coyote gene pool that facilitated an expansion in their geographic range and dietary niche. Furthermore, hybridization between coyotes and domestic dogs may facilitate adaptation to human...

2016
Edward A. Ruiz-Narváez Lara Sucheston-Campbell Jeannette T. Bensen Song Yao Stephen Haddad Christopher A. Haiman Elisa V. Bandera Esther M. John Leslie Bernstein Jennifer J. Hu Regina G. Ziegler Sandra L. Deming Andrew F. Olshan Christine B. Ambrosone Julie R. Palmer Kathryn L. Lunetta

Recent genetic admixture coupled with striking differences in incidence of estrogen receptor (ER) breast cancer subtypes, as well as severity, between women of African and European ancestry, provides an excellent rationale for performing admixture mapping in African American women with breast cancer risk. We performed the largest breast cancer admixture mapping study with in African American wo...

Journal: :Genetics 2014
Konrad Lohse Laurent A F Frantz

Although there has been much interest in estimating histories of divergence and admixture from genomic data, it has proved difficult to distinguish recent admixture from long-term structure in the ancestral population. Thus, recent genome-wide analyses based on summary statistics have sparked controversy about the possibility of interbreeding between Neandertals and modern humans in Eurasia. He...

2016

Estimating ancestry components in Admixture and Structure: Estimated individual ancestry from supervised and unsupervised clustering in Admixture are highly concordant for the autosomes for both migration events, and for the X chromosome for the Neolithic migration scenario. For X-chromosomal ancestry estimated for the steppe migration, however, reference individuals do not emerge as clusters i...

Journal: :Briefings in bioinformatics 2007
Giovanni Montana Clive J. Hoggart

Admixture mapping is a statistical methodology that detects genetic variants in recently admixed populations that are responsible for ethnic differences in disease risk. Three software packages are now available for admixture mapping and we provide a brief overview of the statistical methods and other principal features they implement.

Journal: :Advances in physiology education 2001
P E Bigeleisen

Medical students, residents, and allied health professionals often have difficulty quantitating ventilation-perfusion mismatch in ill patients. This manuscript quantitates ventilation-perfusion mismatch using the underlying physiological concepts and equations that describe mismatch. In addition, clinical problems with diagrams and worked-out solutions are supplied to help students master these...

Journal: :British journal of anaesthesia 1995
M O'Neill N G Vejlstrup B Nagyova K L Dorrington

In order to examine the value of assuming constant pulmonary venous admixture with respect to changes in inspired oxygen fraction (FIO2) and time during sustained unilateral hypoxia, we studied venous admixture for 6 h in 27 anaesthetized rabbits in which the left lung was filled with liquid, isosmotic with plasma. In one group of 10 rabbits the right lung was ventilated for 6 h with FIO2 = 1; ...

Journal: :American journal of human genetics 2004
Giovanni Montana Jonathan K Pritchard

Admixture mapping is a promising new tool for discovering genes that contribute to complex traits. This mapping approach uses samples from recently admixed populations to detect susceptibility loci at which the risk alleles have different frequencies in the original contributing populations. Although the idea for admixture mapping has been around for more than a decade, the genomic tools are on...

Journal: :Investigative ophthalmology & visual science 2015
Arti Tandon Ching J Chen Alan Penman Heather Hancock Maurice James Deeba Husain Christopher Andreoli Xiaohui Li Jane Z Kuo Omolola Idowu Daniel Riche Evangelia Papavasilieou Stacey Brauner Sataria O Smith Suzanne Hoadley Cole Richardson Troy Kieser Vanessa Vazquez Cheryl Chi Marlene Fernandez Maegan Harden Mary Frances Cotch David Siscovick Herman A Taylor James G Wilson David Reich Tien Y Wong Ronald Klein Barbara E K Klein Jerome I Rotter Nick Patterson Lucia Sobrin

PURPOSE To examine the relationship between proportion of African ancestry (PAA) and proliferative diabetic retinopathy (PDR) and to identify genetic loci associated with PDR using admixture mapping in African Americans with type 2 diabetes (T2D). METHODS Between 1993 and 2013, 1440 participants enrolled in four different studies had fundus photographs graded using the Early Treatment Diabeti...

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