cirrhosis is characterized by marked abnormalities in the cardiovascular system. a hyperdynamic splanchnic and systemic circulation is typical of cirrhotic patients and has been observed in all experimental forms of portal hypertension. the hyperdynamic circulation is most likely initiated by arterial vasodilatation, leading to central hypovolemia, sodium retention, and an increased intravascul...

Imputation is a powerful in silico approach to fill in those missing values in the big datasets. This process requires a reference panel, which is a collection of big data from which the missing information can be extracted and imputed. Haplotype imputation requires ethnicity-matched references; a mismatched reference panel will significantly reduce the quality of imputation. However, currently...

THE latest edition of this very valuable book contains much up-to-date information. But although it has been kept rigidly to size it is still a heavy book and I doubt whether many students read it from cover to cover before they qualify. By the time they have qualified a lot of the details of treatment will be out of date (indeed in some instances this is already true). This raises the problem ...

Multicomponent reactions are one of the most interesting concepts in modern synthetic chemistry and, as shown in this critical review, they provide an attractive entry into pyrrole derivatives, which are very important heterocycles from many points of view including medicinal and pharmaceutical chemistry and materials science (97 references).

In this note, we discuss how to efficiently evaluate and assemble general finite element variational forms on H(div) and H(curl). The proposed strategy relies on a decomposition of the element tensor into a precomputable reference tensor and a mesh-dependent geometry tensor. Two key points must then be considered: the appropriate mapping of basis functions from a reference element, and the orie...