OBJECTIVE Endothelial lipase (EL) is a vascular phospholipase that hydrolyzes high-density lipoprotein (HDL) as its preferred substrate. Scavenger receptor-class B type I (SR-BI) is an HDL receptor that mediates the selective uptake of cholesteryl ester. This study investigates the role of EL and SR-BI in the regulation of HDL metabolism in gene knockout mouse models. METHODS AND RESULTS We c...

in this research, 6517 records, collected by khojir sheep breeding station (tehran, iran), during 1991 to 2011 were used to estimate genetic parameters of lamb survival in zandi sheep. genetic parameters were estimated using 16 different models of animal model, sire and threshold models using reml procedures. the aic criterion was used to evaluate the models. the effects in the most suitable an...

Twenty one genotypes of six – parent half diallel were analyzed for estimating gene effects of variance, combining ability and standard heterosis for forage yield and other traits in barley. The estimates of gene effects revealed the significant role of additive genetic component (D) for the inheritance of days to 50% heading, plant height and spikelets per ear. The non-additive component (H1) ...

We derive a statistical model of transcriptional activation using equilibrium thermodynamics of chemical reactions. We examine to what extent this statistical model predicts synergy effects of cooperative activation of gene expression. We determine parameter domains in which greater-than-additive and less-than-additive effects are predicted for cooperative regulation by two activators. We show ...

in this research in order to estimate genetic parameters for milk yield at different milking times for holstein cows of razavi khorasan, a total of 180,462 monthly test day records belonging to first lactation cows calved from 2000 to 2009 were utilized. the records were analysed by a random regression test day model. in the model, the fixed effects of contemporary group of geographical locatio...

The relative proportion of additive and non-additive variation for complex traits is important in evolutionary biology, medicine, and agriculture. We address a long-standing controversy and paradox about the contribution of non-additive genetic variation, namely that knowledge about biological pathways and gene networks imply that epistasis is important. Yet empirical data across a range of tra...

Broccoli and cabbage are important vegetable crops that produce hybrid seeds after insect pollination; the size of floral organs is crucial for this process. To investigate the genetic characteristics of floral organ sizes (corolla width, petal length and width, and lengths of stamen, anther, style, and stigma) and to improve the flower size and breeding efficiency of broccoli, we used multi-ge...