Serotonin transporters (SERTs) have been implicated in various neuropsychiatric disorders. We aim to validate 4-[(18)F]-ADAM (N,N-dimethyl-2-(2-amino-4-[(18)F]fluorophenylthio)benzylamine) as a SERT imaging agent in rats using micro-positron emission tomography (micro-PET) and autoradiography. Sixty to ninety min after injecting 4-[(18)F]-ADAM, specific uptake ratios (SURs) were determined by m...

Krzysztof Ciesielski1, Wojciech Ciesielski2, Adam Rogowski-Tylman1 Received: 19.04.2015 Accepted: 14.05.2015 Published: 30.06.2015 © Pediatr Med Rodz 2015, 11 (2), p. 227–230 Krzysztof Ciesielski1, Wojciech Ciesielski2, Adam Rogowski-Tylman1

Objective To determine the efficacy, tolerability, and safety of ascending doses of Adhesive Dermally-Applied Microarray (ADAM) zolmitriptan versus placebo for acute migraine treatment. Background ADAM is a novel patient-administered system for intracutaneous drug administration. In a phase 1 pharmacokinetic study, zolmitriptan administered using ADAM had much faster absorption than oral admini...

Many membrane-bound proteins undergo proteolytic release from the membrane, a process known as 'shedding'. Some of the processing events are carried out by enzymes of the ADAM (a disintegrin and metalloproteinase) family, which are also membrane bound. One of the most well known ADAM family members is TACE (tumour necrosis factor-alpha-converting enzyme. TACE was the first ADAM family member to...

The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integrin binding motif Arg-Gly-Asp (RGD) in its disintegrin-like domain. This motif is also found in most snake venom disintegrins and other di...

Please cite this article in press as: Steensberg, A. Beyond biomarkers in drug discovery and d 1359-6446/ 2014 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.drudis.2014.12.009 market; this is no longer a certainty. Today, most new drugs compete against numerous therapies, including nonpharmaceutical options. To create new value these therapies need to provide benefits beyond ex...

During the past 25 years, a large amount of distributed virtual environment (DVE) systems has been proposed. Each was built to support a single scenario. This not only makes it impossible to rank these various DVEs, it also obscures the effect of each of the algorithms used in those systems. This makes it very hard to select the algorithms for a new scenario unless this scenario is a fairly exa...

From Marco Polo to Richard Nixon, narratives of the encounter between Chinese and Westerners have been defining texts of European cultures and their descendants. Successive but sporadic reports from travellers, missionaries, diplomats, traders and others have provided a model of an alternative way of arranging people, of organizing their lives, of thinking about the state of being human; one th...