Severe acute pancreatitis (AP) is associated with high morbidity and mortality. Early severity stratification remains a challenging issue to overcome to improve outcomes. We aim to find novel plasma cytokines for the early identification of severe AP according to the revised Atlanta criteria.In this prospective observational study, 30 cytokines, screened semiquantitatively with a human multicyt...

OBJECTIVE The aim of this study was to evaluate the performance of Acute Physiology and Chronic Health Evaluation II (APACHE II), Simplified Acute Physiology Score 3 (SAPS 3), and Acute Physiology and Chronic Health Evaluation IV (APACHE IV) in patients with cancer admitted to intensive care unit (ICU) in a single medical center in China. MATERIALS AND METHODS This is a retrospective observat...

Methods “Papageorgiou” General Hospital is one of the four major hospitals of Thessaloniki, the second largest Greek city of 1.2 million inhabitants. Data was extracted from hospital databases (ICD-10 diagnoses V01-V89 for MT and X60-X84 for SA) from the year 2008 to 2014. Several variables concerning patient demographics, APACHE and SAPS II scores, length of ICU stay (LOS) and outcome were rec...

Selecting patients with severe acute pancreatitis as early as possible after the onset of symptoms is crucial for appropriate treatment [1]. The guidelines indicate that the assessment of severity should be carried out as soon as possible by a scoring system, such as Acute Physiology and Chronic Health Evaluation (APACHE) II which is a grade A recommendation [2, 3]. The comment added by the aut...

OBJECTIVE To assess the performance of Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score II (SAPS II) in Thai critically ill patients. MATERIAL AND METHOD Prospective observational cohort study conducted between July 1, 2004 and October 31, 2005 in the Intensive Care Unit (ICU) of Songklanagarind Hospital, an 800-beds tertiary referral univers...

METHODS: MHI was performed with a Mapleson “C” circuit, 2l-reservoir bag; peak inspiratory pressure was standardized to 35 mL water; and positive expiratory-end pressure of 5 mL water was administered to seven mechanically ventilated patients with septic (6) and cardiogenic (1) shock (67.2 5.2 years, Acute Physiology Assessment and Chronic Health Evaluation II score 22.1 3.1). Diastolic (DAP) a...

We read with interest the letter by Agarwal and Nath [1] in response to our commentary [2] analyzing current evidence for drotrecogin alfa (activated) (DrotAA) in the treatment of severe sepsis. Agarwal and Nath argue that our meta-analysis should have used a fixed-effects model, which ignores between-study heterogeneity, rather than a more conservative random-effects model, which includes it. ...

BACKGROUND Risk adjustment and mortality prediction in studies of critical care are usually performed using acuity of illness scores, such as Acute Physiology and Chronic Health Evaluation II (APACHE II), which emphasize physiological derangement. Common risk adjustment systems used in administrative datasets, like the Charlson index, are entirely based on the presence of co-morbid illnesses. T...

the effect of positive end expiratory pressure (peep) on the hepatic elimination of low to moderate extraction ratio drugs has not been clearly defined. we prospectively investigated the effect of peep on the clearance of theophylline in 30 (20 males and 10 females) intubated critically ill adult patients with acute lung injury/acute respiratory distress syndrome (ali/ards). the mean (±sd) age ...

Background: Hyperglycemia has long been recognized as a common occurrence in critically ill patient, even without history of diabetes mellitus (D.M). Objective: To investigate the role insulin resistance patients with sepsis admitted to medical intensive care unit (ICU) acute hyperglycemia and its relation 30 days outcome. Patients Methods: This study was conducted on 100 adult septic who were ...