The human mannose-binding protein (MBP) appears to function as an "ante-antibody" as its physiological role is in first line host defense. Low baseline serum levels are rapidly increased as part of the acute phase reactant and circulating MBP can act as a direct opsonin or activate the classical alternative complement pathway. MBP appears to selectively recognize an array of apparently disparat...

Plasminogen activator inhibitor-1 (PAI-1) is an important physiological inhibitor of fibrinolysis. It circulates in blood both in free active form and in inactive form complexed with tissue type plasminogen activator (t-PA). Control mechanisms for its synthesis and release from hepatocytes and endothelial cells are important in the pathogenesis of thrombosis. Possible risk factors for myocardia...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : previous reports have suggested acute phase proteins, such as albumin, to alter in hemodialysis (hd) patients. intravenous l-carnitine supplementation is expected to improve the level of plasma albumin in hd patients. this study was performed to evaluate the effects of oral l-carnitine supplementation on hemog...

Elimination half-life and apparent volume of distribution of theophylline were determined in ten healthy volunteers who used smokeless tobacco (snuff or chewing tobacco) regularly but did not smoke cigarettes. Serum concentrations of the acute phase reactant alpha 1-acid glycoprotein (AAG) were also measured. The elimination half-life of theophylline was 9.32 +/- 3.40 hours (mean +/- standard d...

C r o h n’s d i s e a s e ( C D ) is a heterogeneous, chronic in ammatory disease primarily affecting the gastrointestinal tract. Secondary systemic (AA) amyloidosis is a rare but serious complication and a major cause of death in patients with CD setting long-term mortality between 40% and 60% [1-3]. Renal involvement is the most common manifestation of AA amyloidosis, ranging from nephrotic s...

background: the acute phase response is beneficial to theanimal in restoring homeostasis, and measuring the circulatingacute phase proteins, cytokines, and enzymes can be used toevaluate the innate immune system's responses to invader agentssuch as bacterial lipopolysaccharide. measurement of theseparameters has shown to be useful as diagnostic and prognosticmarkers in animal endotoxemia. objec...