Activation of the innate immune system has been postulated in the pathogenesis of Huntington's disease (HD). We studied serum concentrations of C-reactive protein (CRP) and low albumin as positive and negative acute-phase proteins in HD. Multivariate linear and logistic regression was used to study the association between acute-phase protein levels in relation to clinical, neuropsychiatric, cog...

background: high sensitive c-reactive protein (hs-crp) is a systemic inflammatory marker that is produced in a large amount by hepatocytes in response to interleukin-1 (il-1), il-6 and tumor necrosis factor after ischemic stroke. methods: measurement of hs-crp in the first 24 hours of onset in 162 patients suffering from ischemic stroke was done. relation of crp with the risk of early mortality...

introduction: we evaluated the incidence and clinical outcome of patients with hypertensive acute ischemic stroke (ais) admitted to a tertiary care center in central india. in addition, we examined the status of stroke biomarkers namely neuron-specific enolase (nse), glial specific protein (s-100ββ), and inter-α-trypsin inhibitor heavy chain 4(itih4) in the serum of patients suffering from ais ...

Inhalation of ambient and workplace particulate air pollution is associated with increased risk of cardiovascular disease. One proposed mechanism for this association is that pulmonary inflammation induces a hepatic acute phase response, which increases risk of cardiovascular disease. Induction of the acute phase response is intimately linked to risk of cardiovascular disease as shown in both e...

Transplantation of Yoshida sarcoma (solid type) and Zajdela ascites hepatoma tumors in rats induces a biphasic change in the concentration of the following five acute-phase proteins: alpha-1-acid glycoprotein; alpha-1-antitrypsin; haptoglobin; hemopexin; and ceruloplasmin. These proteins and other plasma proteins were quantitated by two-dimensional immunoelectrophoresis relative to normal serum...

The serum protein α1-acid glycoprotein (AGP), also known as orosomucoid, is generally described as an archetypical positive acute phase protein. Here, porcine AGP was identified, purified and characterized from pooled pig serum. It was found to circulate as a single chain glycoprotein having an apparent molecular weight of 43 kDa by SDS-PAGE under reducing conditions, of which approximately 17 ...

A new acute phase plasma component has been found in mice exposed to certain toxic materials and pathogenic bacteria. The abnormal component, detected by immunodiffusion employing absorbed antiserum, was chiefly studied in plasma of streptolysin O-treated mice where it appears within 24 hours after intravenous administration of a sublethal dose of the toxin. The new factor is a protein having t...

University of Veterinary Medicine and Pharmacy, Košice, Slovak Republic (Received 1 March 2013) The aim of this study was to evaluate the serum proteins electrophoretic pattern and the concentrations of acute phase proteins in calves with chronic bronchopneumonia. Twenty-eight calves with clinical symptoms of disease were included into the evaluation. Blood serum was analyzed for total protein ...