Aripiprazole is a second-generation antipsychotic with a unique pharmacologic receptor profile that has efficacy in the treatment and prevention of mania in bipolar I disorder. This article reviews the evidence supporting treatment of adults with bipolar I disorder using aripiprazole as monotherapy or adjunctively during acute mania and its utility as an intramuscular agent for agitation in man...

Objectives Lithium is still recommended as a first-choice treatment for acute bipolar mania, especially in pure euphoric mania of mild to moderate severity. Despite the large quantity of evidence supporting the efficacy of lithium, in clinical practice its use has often been limited because of management issues related to its narrow therapeutic index. International guidelines suggest combining ...

BACKGROUND Epidemiological, clinical, and high-risk studies have provided evidence that the peak period for onset of diagnosable episodes of mania and hypomania starts in mid-to-late adolescence. Moreover, clinically significant manic symptoms may occur even earlier, especially in children at familial risk. Lithium is the gold standard treatment for acute mania in adults, yet to our knowledge, ...

On the 17th July last, a male, aged about 24 years, suddenly developed an attack of acute mania needing physical restraint. I was called in to see the man and found him with the following symptoms:? The patient had to be controlled in bed by four attendants; he was talking foolishly but articulated distinctly; his eyes were shut and he resisted their being opened; Babinski's and Kernig's signs ...

OBJECTIVE Novel antipsychotics are increasingly used in the treatment of bipolar and schizoaffective mania. This paper presents an overview of the controlled studies in this field. METHOD Using cross-references, a computerized search was performed on MEDLINE and EMBASE psychiatry covering the period 1990-2002. RESULTS Olanzapine and risperidone, added to mood stabilizers, and olanzapine as ...

BACKGROUND Although 5-hydroxytryptamine (5-HT) has been implicated in mania, the precise alterations in the 5-HT system remain elusive. AIMS To assess brain 5-HT2 receptors in drug-free individuals experiencing a manic episode in comparison with healthy volunteers using positron emission tomography (PET). METHOD Participants (n = 10) with DSM-IV bipolar I disorder-manic episode and healthy ...