Evaluation the Effect of Chemotherapy Drugs and Thiosemicarbazone Complexes on Expression URHC CASC15 LncRNAs in Acute Lymphoblastic Leukemia Cell Line

acute lymphoblastic leukemia is the most common form of pediatric cancer which is categorized into three l1, l2, and l3 and could bedetected through screening of blood and bone marrow smears by pathologists. due to being time‑consuming and tediousness of theprocedure, a computer‑based system is acquired for convenient detection of acute lymphoblastic leukemia. microscopic images areacquired fro...

C hronic lymphocytic leukemia (CLL) is a frequent CD5 + B-cell neoplasia that involves peripheral blood, bone marrow, lymph nodes and other lym-phoid tissues. The median age of patients at diagnosis of CLL is around 70 years old and the prognosis is extremely variable. In spite of some advances in its therapy, CLL continues to be incurable. Due to this fact, and to the prognos-tic heterogeneity...

MicroRNAs (miRNAs, miRs) are small endogenous non-coding RNAs that regulate the expression of protein-encoding genes at the post-transcriptional level. Several studies have described the role of miRNAs in T-cell acute lymphoblastic leukemia (T-ALL), including tumor suppressor and oncogenic miRNAs. Down-regulation of miRNA expression is a prominent feature of human malignancy. This down-regulati...

introduction: despite achievements in treating acute lymphoblastic leukemia (all) in children, its burden on the psychosocial status of patients is not well defined yet. this study aims to determine the impact of childhood all on emotional and behavioral pattern of the patients compared to healthy peers as assessed by the child behavior checklist (cbcl). methods: we studied 100 children with al...

BACKGROUND Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children and represents approximately 25% of cancer diagnoses among those younger than 15 years of age. AIM AND OBJECTIVES This study investigated substitutions in the ATP synthase subunit 6 gene of mitochondrial DNA (mtDNA) as a potential diagnostic biomarker for early detection and diagnosis of acute lympho...

BACKGROUND MicroRNA regulate the activity of protein-coding genes including those involved in hematopoietic cancers. The aim of the current study was to explore which microRNA are unique for seven different subtypes of pediatric acute lymphoblastic leukemia. DESIGN AND METHODS Expression levels of 397 microRNA (including novel microRNA) were measured by quantitative real-time polymerase chain...

Background and Aims: DNA methyltransferase3A (DNMT3A) is necessary for the adjustment of gene expression, and the mutations in the DNMT3A gene are reported in a variety of leukemia cases. DNMT3A mutations are during cancer progression and cause poor prognosis in many leukemias. Thus, this gene can be a target for new treatments. This study aimed to examine the distribution of DNMT3A mutations i...