Abstract The specific niche adaptations that facilitate primary disease and Acute Lymphoblastic Leukaemia (ALL) survival after induction chemotherapy remain unclear. Here, we show Bone Marrow (BM) adipocytes dynamically evolve during ALL pathogenesis therapy, transitioning from cellular depletion in the leukaemia to a fully reconstituted state upon remission induction. Functionally, adipocyte n...

B-cell acute lymphoblastic leukaemia (B-ALL) reprograms the surrounding bone marrow (BM) stroma to create a leukaemia-supportive niche. To elucidate contribution of immune cells leukaemic microenvironment, we investigated involvement monocyte/macrophage compartments, as well several recruitment pathways in B-ALL development. Immunohistochemistry analyses showed that CD68-expressing macrophages ...