Background: The heart and great vessels were once thought to be relatively resistant to the damaging effect of radiation therapy. There is now clear evidence that thoracic irradiation may cause acute inflammation and progressive fibrosis of different structures, including the heart valves, the myocardium and the pericardium, the coronary arteries and the conduction system. As new therapies have...

Studies examining acute oxygenation and perfusion changes in irradiated skin are limited. Hyperspectral imaging (HSI), a method of wide-field, diffuse reflectance spectroscopy, provides noninvasive, quantified measurements of cutaneous oxygenation and perfusion. This study examines whether HSI can assess acute changes in oxygenation and perfusion following irradiation. Skin on both flanks of nu...

The role of the pprI gene from Deinococcus radiodurans R1 in therapy of acute radiation injury of a mammalian host was investigated. We injected a plasmid containing the pprI gene into the muscle of mice exposed to total 6Gy of 60Co γ-ray radiation. After injection, we used in vivo gene electroporation technology to transfer the pprI gene into the cell. We found the PprI protein was expressed s...

PURPOSE In the 1970s and 80s, standard treatment for childhood acute lymphocytic leukemia (ALL) included both intrathecal methotrexate and whole-brain irradiation. During acute treatment, seizures were not uncommon. The development of intractable epilepsy years after treatment, however, has not been well described in the literature. We describe five patients who were treated for acute lymphocyt...

We evaluated the growth of children with acute leukemia who received a bone marrow transplant (BMT) after preparation with hyperfractionated total body irradiation (TBI). Seventy-two patients (27 female and 45 male patients) with acute lymphoblastic leukemia (ALL; n = 39) or acute myelogenous leukemia (AML; n = 33) who were l e u than 14 years of age at BMT were studied. Before BMT all had rece...

A randomized trial was performed to compare two regimens of total body irradiation in patients with chronic myeloid leukemia treated by allogeneic marrow transplantation while in the chronic phase. All patients received cyclophosphamide 120 mg/kg followed by total body irradiation and marrow from HLA-identical siblings. Cyclosporine and methotrexate were used for prophylaxis against acute graft...

Mice bearing NCTC 2472 tumors (either solid or ascitic) were continuously irradiated at 50 rads/hr in order to simulate a dose rate comparable to that generated by tissue implants. Kinetic and survival data were collected over a 40-hr interval on cells obtained from tumors and also from bone marrow. Bone marrow cellularity decreased rather slowly. At 40 hr it was 10% of the control value. The n...

In this issue of Blood, authors of 2 articles have compared busulfan with total body irradiation (TBI) in preparative regimens for hematopoietic transplantation as treatment of acute myeloid leukemia (AML).

introduction: due to its immunosuppressive properties, local graft irradiation (lgi) has been proposed as a second line therapy for treatment of acute kidney rejection. case presentation: in this case-series we report 6 patients with biopsy proven acute kidney allograft rejection refractory to conventional antirejection therapy who underwent lgi for treatment of acute rejection at our center. t...