A 17-year-old girl presented with a 3-day history of epistaxis, vaginal bleeding and petechiae over the lower extremities. The patient had been feeling unwell with productive cough, fever, chills, poor appetite and weight loss for 2 months. Laboratory findings revealed anemia and thrombocytopenia, whereas bone marrow examination was unremarkable. She was diagnosed as having idiopathic thrombocy...

Eight non-splenectomized patients with corticosteroid-refractory idiopathic thrombocytopenic purpura (ITP) were treated with low-dose vincristine (1 mg/week up to a total dose of 4 mg). Complete remission was achieved in 2 cases and partial remission in 3. Bleeding stopped in one patient who failed to remit. No statistical relationship was found between the response to vincristine and the durat...

Coombs' negative autoimmune hemolytic anemia (AIHA) is a rare disease which shares similar clinical and hematological features with Coombs' positive AIHA, but its exact frequency remains unknown. There have been few reports of idiopathic thrombocytopenic purpura (ITP) and Coombs' negative AIHA associated with other lymphoproliferative disorders (LPDs). Since there is a well known association be...

By BERNARD CZERNOBILSKY, HOWARD H. FREEDMAN AND ABRAHAM M. FRUMIN F OAMY HISTIOCYTES were found in three of 47 spleens removed for chronic idiopathic thrombocytopenic purpura ( ITP) . Fat stains demonstrated the absence of lipid. These cells have never been reported in ITP except for a brief mention by Carpenter et a!.’ Somewhat similar histiocytes have been described in thalassemia2, and in an...

Thrombotic thrombocytopenic purpura (TTP) is caused by the persistence of the highly reactive high-molecular-weight multimers of von Willebrand factor (VWF) due to deficiency of the specific VWF-cleaving protease (VWF-CP) ADAMTS13, resulting in microangiopathic disease. The acquired form is caused by autoantibodies against VWF-CP, whereas homozygous or compound heterozygous mutations of ADAMTS1...

Thrombotic thrombocytopenic purpura (TTP) is caused by the persistence of the highly reactive high-molecular-weight multimers of von Willebrand factor (VWF) due to deficiency of the specific VWFcleaving protease (VWF-CP) ADAMTS13, resulting in microangiopathic disease. The acquired form is caused by autoantibodies against VWF-CP, whereas homozygous or compound heterozygous mutations of ADAMTS13...

Catastrophic antiphospholipid syndrome (APS) is caused by thrombotic vascular occlusions that affect both small and large vessels, producing ischemia in the affected organs as well as a systemic inflammatory response syndrome (SIRS). We report a case of a patient with idiopathic thrombocytopenic purpura (ITP) who developed massive cerebral ischemia due to this entity. Prompt and aggressive trea...

© 2015 The Authors. doi: 10.2340/00015555-1964 Journal Compilation © 2015 Acta Dermato-Venereologica. ISSN 0001-5555 Mucous membrane pemphigoid (MMP) is an autoimmune subepidermal blistering disease involving primarily the mucosae and occasionally the skin (1–3). We report here a case of a Japanese male patient with idiopathic thrombocytopenic purpura (ITP) who later developed MMP with IgG auto...

Idiopathic thrombocytopenic purpura (ITP) is the most common acquired bleeding disorder in childhood. ITP is characterized by a lo� circulating platelet count caused principally by destruction of antibody-coated platelets in the reticuloendothelial system. It can be classified into t�o major forms, acute and chronic. Acute ITP is usually a benign self-limiting condition �ith a high probability ...

mediastinal neoplasms are uncommon tumors that can occur at any age but are most common through the fifth decades of life. a wide variety of systemic disorders are associated with 71% of thymomas. the symptoms of these as sociated disorders often lead to the original discovery of the mediastinal tumor. a 35-year-old female with petechia and purpura was admitted to sina hospital of the city of h...