Maximal aerobic capacity (Vo(2max)) decreases progressively with age, primarily because of a reduction in maximal cardiac output (Q(max)). This age-associated decline in Vo(2max) may be partially mediated by the development of oxidative stress that can suppress beta-adrenergic-receptor responsiveness and, consequently, reduce Q(max). To test this hypothesis, Vo(2max) (indirect calorimetry) and ...

Background: Zinc is essential for nucleic acid metabolism, protein synthesis and tissue healing. Zinc deficiency has detrimental effects on child health and increases mortality rate of pneumonia and gastroenteritis. By improving absorptive function of villous cells and by reducing pathogenic enterobacteriaceae in lumen, Zinc improves diarrhea outcome in children. Previous studies in developing ...

By SIDNEY FARBER, M.D. T HE PRODUCTION of temporary remissions in the course of acute leukemia in children by the administration of the compound, 4-aminopteroylglutamic acid ( aminopterin)’ ‘ ‘-a biologic antagonist to folic acid*_has raised a number of theoretic and practical questions. Confirmation of this finding has been reported from several sources3; temporary remissions equally impressiv...

Cyclizine (1-benzhydryl-4-methyl-piperazine, CAS 82-92-8, CYC, I), a piperazine derivative, belongs to H1 antihistamine group of drugs that shows such pharmacological properties as anti-inflammatory, anti-allergic and anti-platelet effects, similar to other H1-receptor antagonists. In this study, two new tolyl and cumene derivatives of I (1-ethyl-4-[(p-isopropylphenyl) (p-tolyl) methyl]-piperaz...

Objective: Acute chest pain is an important and frequently occurring symptom in patients. Chest pain is often a sign of ischemic heart disease. Chest pain due to suspected Acute Coronary Syndrome (ACS) is responsible for a large and ijncreasing number of hospital attendances and admissions. Current practice for suspected ACS involves troponin testing 10–12 hours after symptom o...

By SIDNEY FARBER, M.D. T HE PRODUCTION of temporary remissions in the course of acute leukemia in children by the administration of the compound, 4-aminopteroylglutamic acid ( aminopterin)’ ‘ ‘-a biologic antagonist to folic acid*_has raised a number of theoretic and practical questions. Confirmation of this finding has been reported from several sources3; temporary remissions equally impressiv...

Objective(s): Calcitonin gene related peptide (CGRP) receptors are widely distributed in the central nervous system. The aim of this study was to investigate the effects of intracerebroventricular (ICV) injection of CGRP on pain behavioral responses and on levels of monoamines in the periaqueductal gray area (PAG) during the formalin test in rats.Materials and Methods: Twenty-four male rats wer...

Background and Objective: Regarding side effects of acute and especially chronic inflammation and incomplete treatment of patients suffering from these side effects, the new and effective strategies are needed. For this purpose, in the present study, we scientifically evaluate an introduced folk herb Urtica dioica, for treatment of inflammation. Materials and Methods: The Sham, control and trea...

in vivo microdialysis was used to study the effects of morphine on glutamate release from the ventral tegmentum area (vta) in freely moving rats. intraperitoneal (i.p.) injection of acute and repeated morphine at increasing doses significantly enhanced glutamate release. only a minor tolerance developed to this dosage of morphine. ap-s (2-amino-5-phosphonovaleric acid, 0.5 mg/kg i.p.), a nmda r...