BACKGROUND Infection with Wuchereria bancrofti can cause severe disease characterized by subcutaneous fibrosis and extracellular matrix remodeling. Matrix metalloproteinases (MMPs) are a family of enzymes governing extracellular remodeling by regulating cellular homeostasis, inflammation, and tissue reorganization, while tissue-inhibitors of metalloproteinases (TIMPs) are endogenous regulators ...

BACKGROUND Mycobacterium tuberculosis infection in humans results in either latent infection or active tuberculosis. We sought to determine whether a higher frequency of regulatory T (T(reg)) cells predispose an individual toward active disease or whether T(reg) cells develop in response to active disease. METHODS In cynomolgus macaques infected with a low dose of M. tuberculosis, approximate...

background : bacterial infections in burn and wound patients are common and difficult to control. the aim of the current study was to evaluate the ability of full length oprf to elicit the production of protective igg in mice burn wound sepsis model against p. aeruginosa infection. methods : oprf protein was expressed and purified by ni-nta. the purified protein as used to immunize balb/c mice....

infection and the development of MPO-ANCA-associated GN, we compared the titres of C. pneumoniae abs in the active and remission phase of the disease in the same patients. The titres of anti-C. pneumoniae IgM and IgA, but not IgG abs in ANCA (remission) group significantly decreased compared with that in ANCA (active) [IgM ab: 1.22 0.47 vs 1.05 0.49U, P< 0.05; IgA ab: 1.70 1.20 vs 1.29 0.88 U, ...