نتایج جستجو برای: active bone formation

تعداد نتایج: 1210715  

Journal: :Journal of the Royal Society, Interface 2009
Chikara Ohtsuki Masanobu Kamitakahara Toshiki Miyazaki

Bioactive ceramics have been used clinically to repair bone defects owing to their biological affinity to living bone; i.e. the capability of direct bonding to living bone, their so-called bioactivity. However, currently available bioactive ceramics do not satisfy every clinical application. Therefore, the development of novel design of bioactive materials is necessary. Bioactive ceramics show ...

Journal: :Therapeutics and Clinical Risk Management 2009
Silvia Migliaccio Marina Brama Nazzarena Malavolta

Glucocorticoids (GC)-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis, which leads to an increased fracture risk in patients. The normal bone turnover depends on a balance between osteoblasts and osteoclasts activity and GC can cause a rapid bone loss, decreasing bone formation and increasing bone resorption. The decreased bone formation is mainly due to the GC-ind...

Background and purpose: Reconstruction of bone defects remains one of the most challenges encountered by orthopedic and reparative surgeons. The purpose of this study was to assess the osteogenic potential of octacalcium phosphate (OCP) and octacalcium phosphate/gelatin (OCP/G) composite in the tibia bone defects in rats. Materials and methods: This experimental study was conducted in 72 mal...

Journal: :The Japanese Journal of Urology 1965

Journal: :research in molecular medicine 0
aliasghar tehrani department of pathology, faculty of veterinary medicine, university of urmia, urmia, iran asghar morvaridi department of pathology, faculty of veterinary medicine, university of urmia, urmia, iran babak beikzadeh phd students of immunology, faculty of veterinary medicine, university of tehran, tehran, iran anahita pirtaj hamedani veterinary students, faculty of veterinary medicine, university of urmia, urmia, iran fatemeh khadir veterinary students, faculty of veterinary medicine, university of urmia, urmia, iran mahla mohamadi veterinary students, faculty of veterinary medicine, university of urmia, urmia, iran

background: fluoride (f−) is a trace element that is incorporated into bone mineral during bone formation. this study assessed the effect of increasing fluoride doses on the bone formation and microarchitecture on the femur of rats by histological, and histometrical methods. materials and methods: a total of 16 rats was divided into one group of control and three groups of animals that received...

Journal: :Journal of musculoskeletal & neuronal interactions 2002
J Rosen A Negro-Vilar

A novel approach to the treatment of osteoporosis in men, and possibly women, is the development of selective androgen receptor modulators (SARMs) that can stimulate formation of new bone with substantially diminished proliferative activity in the prostate, as well as reduced virilizing activity in women. Over the last several years, we have developed a program to discover and develop novel, no...

2016
Mehmet Ozer Dokmeci Ali Murat Kalender Resit Sevimli Mehmet Fatih Korkmaz Okkes Bilal

Bone is an active and dynamic tissue that builds up the skeleton support of the organism and regenerates itself continuously for a life time [1]. Bone tissue is a very important structure that constitutes the frame in human body in order for the organs to work properly, and the disruption of its integrity is defined as fracture. This pathology formation negatively affects neighboring soft tissu...

Journal: :PLoS ONE 2008
Charles A. O'Brien Lilian I. Plotkin Carlo Galli Joseph J. Goellner Arancha R. Gortazar Matthew R. Allen Alexander G. Robling Mary Bouxsein Ernestina Schipani Charles H. Turner Robert L. Jilka Robert S. Weinstein Stavros C. Manolagas Teresita Bellido

Osteocytes, former osteoblasts buried within bone, are thought to orchestrate skeletal adaptation to mechanical stimuli. However, it remains unknown whether hormones control skeletal homeostasis through actions on osteocytes. Parathyroid hormone (PTH) stimulates bone remodeling and may cause bone loss or bone gain depending on the balance between bone resorption and formation. Herein, we demons...

Journal: :European journal of orthodontics 1996
M Sawada N Shimizu

The most intense endogenous transforming growth factor (TGF)-beta 1 expression was detected in osteoblasts and fibroblasts in the mid-palatal suture 24 hours after the start of palatal expansion with an immunohistochemical technique. Based on these data, local effects of transforming growth factor-beta 1 (TGF-beta 1) in the expanding mid-palatal suture of the rat were examined. Single doses of ...

2017
Marina Bolzoni Domenica Ronchetti Paola Storti Gaetano Donofrio Valentina Marchica Federica Costa Luca Agnelli Denise Toscani Rosanna Vescovini Katia Todoerti Sabrina Bonomini Gabriella Sammarelli Andrea Vecchi Daniela Guasco Fabrizio Accardi Benedetta Dalla Palma Barbara Gamberi Carlo Ferrari Antonino Neri Franco Aversa Nicola Giuliani

Bone marrow monocytes are primarily committed to osteoclast formation. It is, however, unknown whether potential primary alterations are specifically present in bone marrow monocytes from patients with multiple myeloma, smoldering myeloma or monoclonal gammopathy of undetermined significance. We analyzed the immunophenotypic and transcriptional profiles of bone marrow CD14+ monocytes in a cohor...

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