OBJECTIVES To evaluate a novel series of quinoxaline 1,4-di-N-oxides for in vitro activity against Mycobacterium tuberculosis and for efficacy in a mouse model of tuberculosis (TB). METHODS Ketone and amide derivatives of quinoxaline 1,4-di-N-oxide were evaluated in in vitro and in vivo tests including: (i) activity against M. tuberculosis resistant to currently used antitubercular drugs incl...

Chronic bacterial biofilms place a massive burden on healthcare due to the presence of antibiotic-tolerant dormant bacteria. Some of the conventional antibiotics such as erythromycin, vancomycin, linezolid, rifampicin etc. are inherently ineffective against Gram-negative bacteria, particularly in their biofilms. Here, we report membrane-active macromolecules that kill slow dividing stationary-p...

abstract aims: one of the consequences of taking ground water into surface is changing its chemical quality, specially increasing the concentration of dissolved salts. this research was performed in order to analyze growth possibility of heterotrophic bacteria in the membrane of active desalination plants in kashan city, iran. instrument & methods: this descriptive cross-sectional study was don...

Bacteriophage particles are called active when they are able to give rise to production of active phage following adsorption on their specific host bacterium. This is generally detected by the formation of a plaque when plated on nutrient agar by standard techniques (Adams, 1950). If the particles are exposed to ultraviolet light, a fraction of them loses the ability to give rise to production ...

antibiotic resistance is a phenomenon in which antibiotic used to treat bacteria becomes useless due to resistance mechanism. increased drug resistance and occurrence of multiple drug resistance in bacteria specificity nosocomial and urinary tract infection bacteria has reduced the possibilities of treating these infectious diseases. efflux pumps are one of the major mechanism of mdr in bacteri...

Marine bacteria were isolated from seawater was collected from different coastal areas of the Tamilnadu Sea. The antimicrobial activities of these bacteria were investigated. Ethyl acetate extracts of marine bacterial fermentation were screened for antimicrobial activities using the method of agar diffusion. The results showed that 25 strains of the isolates have antimicrobial activity. The pro...

We developed a novel active nanocarrier of common antibiotics, which can efficiently degrade biofilms resistant bacteria and bypass their defences.

OBJECTIVE To assess the co-colonization rates of extended-spectrum beta-lactamase (ESBL)-producing bacteria and vancomycin-resistant Enterococcus (VRE) obtained on active surveillance cultures. DESIGN Prospective cohort study. SETTING Medical and surgical intensive care units (ICUs) of a tertiary-care hospital. PATIENTS Patients admitted between September 2001 and November 2002 to the med...

Rapid phenotyping of bacteria to identify drug-resistant strains is an important capability for the treatment and management of infectious disease. At present, the rapid determination of antibiotic susceptibility is hindered by the requirement that, in existing devices, bacteria must be pre-cultured for 2-3 days to reach detectable levels. Here we report a novel electrochemical approach that ac...