This chapter provides a review and evaluation of the literature pertinent to joint toxic action of the mixture and its components. The text is generally organized so that human data are presented first, and studies are grouped by route, and by endpoint where that is feasible. In Section 2.2, summary tables are provided at the end of each section on the binary mixtures. The tables are designed t...

Presently, many communication protocols are under development which are tailored to the eecient high-speed data transfer meeting diierent application-speciic requirements. Our approach concentrates on a framework which facilitates the formal veriication of the protocols. The framework supplies veriied and re-usable implications between predeened protocol and service speciication components. For...

Ribosome-inactivating proteins (RIP) are RNA N-glycosidases that inactivate ribosomes by specifically depurinating a conserved adenine residue at the α-sarcin/ricin loop of 28S rRNA. Recent studies have pointed to the involvement of the C-terminal domain of the eukaryotic stalk proteins in facilitating the toxic action of RIPs. This review highlights how structural studies of eukaryotic stalk p...

Several different receptor proteins have been identified that bind monomeric, oligomeric, or fibrillar forms of amyloid-β (Aβ). "Good" receptors internalize Aβ or promote its transcytosis out of the brain, whereas "bad" receptors bind oligomeric forms of Aβ that are largely responsible for the synapticloss, memory impairments, and neurotoxicity that underlie Alzheimer disease. The prion protein...

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Accumulation of beta amyloid (Aβ) in the brain is a primary feature of Alzheimer's disease (AD) but the exact molecular mechanisms by which Aβ exerts its toxic actions are not yet entirely clear. We documented pathological changes 3 and 6 months after localised injection of recombinant, bi-cistronic adeno-associated viral vectors (rAAV2) expressing human Aβ40-GFP, Aβ42-GFP, C100-GFP or C100(V71...

In a one-year follow-up study, 444 blood histamine determinations were performed in 163 patients with solid malignant tumours. Compared with normal subjects, blood histamine levels were significantly lower in patients with unresected primary tumours (30.7 + 19.9 ngml -), metastases (34.1 + 17.1 ngml -), or both (24.5+12.8ngml-1). By contrast, after successful tumour resection, histamine blood l...

In this thesis we present a novel approach to the specification of mobile systems. By mobile system we mean a system that makes use of code that can be transmitted from one computer to another one at runtime, so that the execution is continued on the new computer. Such systems are often modelled as a hierarchy of locations whose structure can be modified. This is also the starting point for our...

in vietnam, municipal solid waste (msw) has being become increasing complex due to variety of reasons as the increasing quantity, changing composition of msw, rising public awareness and municipal administration policies among different cities and surrounding communities. there is not currently an efficient management system in place for facilities such as storage, collection, transfer, tran...

A homotopy action of a group G on a space X is a homomorphism from G to the group HAUT(X) of homotopy classes of homotopy equivalences of X. George Cooke developed an 'obstruction theory to determine if a homotopy action is equivalent up to homotopy to a topological action. The question studied in this paper is: Given a diagram of spaces with homotopy actions of G and maps between them that are...