Mangrove-derived actinomycetes are promising sources of bioactive natural products. In this study, using homologous screening of the biosynthetic genes and anti-microorganism/tumor assaying, 163 strains of actinomycetes isolated from mangrove sediments were investigated for their potential to produce halogenated metabolites. The FADH2-dependent halogenase genes, identified in PCR-screening, wer...

The enzyme Asparaginase, known as L-asparagine amidohydrolase, has anti-tumor properties and is widely used a chemotherapeutic treatment for acute lymphoblastic leukemia. Many different organisms, including plants terrestrial microbes such bacteria, fungi, algae actinomycetes, have produced this enzyme. In study, 34 isolates of the actinomycetes were collected from soil water governorates in Eg...

Actinomycetes are a diverse group of medically, industrially and ecologically important bacteria, studied as much for the diseases they cause as for the cures they hold. Along with also as a source of industrial important product which are helpful for mankind. However, many of the rare genera of actinomycetes have been neither explored nor manipulated for their biotechnological and industrial p...

Secondary Metabolites of Soil Actinomycetes, UTMC 676 and 919, Induces Apoptosis in Human Non‑Small-Cell Lung Cancer Cell Line

Screening of microorganisms for the production of novel antibiotics has been intensivelypursued for many years by scientists. Actinomycetes have the capability to synthesize manydifferent antibiotics. A total of 69 actinomycete isolates were recovered from soil samplescollected from Alborz Province. Selected colonies (rough, chalky) of actinomycetes werepurified. All screened isolates were iden...

Antibiotic drug discovery is an indispensable process to combat aggressive ability of pathogenic microorganisms and emerging infectious diseases against health and well-being of people throughout the world. According to the updated and expanded data on natural products presented by Newman and Cragg (2012), the utility of natural products as sources of novel structures is still alive and the ant...

Agar media made with 0.4% colloidal chitin plus mineral salts and adjusted to pH 8.0 was superior to four other commonly used media for the isolation and enumeration of actinomycetes from water samples. More actinomycetes developed on chitin agar, and the development of bacteria and fungi was suppressed. Frozen and vacuum-dried chitin from aqueous colloidal suspensions was finely divided and ga...

The purpose of this work was to screen the actinomycetes having antitumor or antimicrobial activity, which were isolated from the surface, epidermis and intestines of sea plants and animals collected from the Taiwan Strait, China. Antitumor activity was studied by the MTT assay and DNA target activity was studied by the biochemical induction assay while antimicrobial activity was determined by ...

Salt-tolerant alkaliphilic actinomycetes are difficult to isolate as their natural environments are much more different and hostile than laboratory conditions. Due to these limitations, majority of the microbial population remain uncultivated. During the recent years, development and application of molecular techniques, such as; DGGE, TGGE, RFLP and DNADNA hybridization have proved quite valuab...

Actinomycetes are filamentous, Gram-positive bacteria widely distributed in soil and can produce secondary metabolites useful as antibiotics. The synthesis of is influenced by the growth conditions each isolate, including fermentation period. Klebsiella pneumoniae an opportunistic bacterial pathogen causing lower respiratory tract infection. Objectives: To determined inhibition activity with di...