The equilibrium of stacked and unstacked base pairs is of central importance for all nucleic acid structure formation processes. The stacking equilibrium is influenced by intramolecular interactions between nucleosides but also by interactions with the solvent. Realistic simulations on nucleic acid structure formation and flexibility require an accurate description of the stacking geometry and ...

Acid-base derangements are among the most common abnormalities seen in critically ill patients [1]. They are generally associated with clinical outcome and disease severity, especially for metabolic acidosis [1,2]. Thus, understanding the nature of these disorders is fundamental to the practice of critical care medicine. The classical approach to acid-base disorders is based on the Henderson-Ha...

ess the relationship between umbilical cord blood gases at birth and morphology of umbilical cord, in a prospective study of 200 consecutive term delivery, we investigated the relationship between umbilical cord morphology characteristics (umbilical crd length, number of vascular coil, coiling index) and color of amniotic fluid and umbilical vessel blood gases. statistically significant linear ...

in this study, bis(salicylaldehyde)-4-methyl-1,2-phenylenediimine (bsmp) as a schiff base ligand of n2o2-type and its mn and fe complex as m-bsmp catalyst were synthesized and characterized by uv-vis, ir spectroscopy and elemental analysis. the efficiency of fe- and mn-bsmp catalysts was evaluated in the oxidative decarboxylation of arylacetic acids with tetra-butylammonium periodate (n-bu4nio4...

Quadriceps femoris muscle needle biopsies were performed in ten patients with chronic obstructive pulmonary disease and acute respiratory failure and in ten age- and sex-matched healthy control subjects. The main indices of skeletal muscle cell energy metabolism, intracellular acid-base equilibrium and lactate metabolism were evaluated. Reduced ATP and phosphocreatine content, intracellular aci...

Currently, the molecular mechanisms of the acid-base equilibrium maintenance in the body remain poorly understood. The development of alkalosis under various pathological conditions poses an immediate threat to human life. Understanding the physiological mechanisms of alkalosis compensation may stimulate the development of new therapeutic approaches and new drugs for treatment. It was previousl...

The article presents influence of pH and glucose concentration on phenylboronic acid (PBA) fluorescence studied by steady-state and time-resolved measurements. Fluorescence of PBA decreases with growing pH. These changes reflected acid-base equilibrium of PBA and allowed to estimate value of pKd as 9.2, which is comparable with literature data. Fluorescence intensity of phenylboronic acid is qu...

Upon the addition of protons to an aqueous solution containing multiple buffers, the final H+ concentration ([H+]) at equilibrium is determined by the partitioning of added H+ among the various buffer components. In the analysis of acid-base chemistry, the Henderson-Hasselbalch equation and the Stewart strong ion formulation can only describe (rather than predict) the equilibrium pH following a...