The available informations on the genotoxic effects in experimental systems of the antiherpesvirus nucleosides aciclovir, penciclovir, ganciclovir, brivudine and cidofovir as well as of the antiretrovirals zidovudine (AZT), lamivudine, zalcitabine (ddC), didanosine and stavudine are reviewed. Furthermore, data on carcinogenic activity of these drugs in laboratory rodents are compiled. Most nucl...

In the 1980s the outcome of patients with herpes simplex encephalitis was shown to be dramatically improved with aciclovir treatment. Delays in starting treatment, particularly beyond 48 h after hospital admission, are associated with a worse prognosis. Several comprehensive reviews of the investigation and management of encephalitis have been published. However, their impact on day-to day clin...

Epstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. The liver is involved in 80-90% of patients in a self-limiting transient manner, with jaundice being much more uncommon (5%). From a hematological standpoint it may ma...

Hippocrates was the first to describe lesions that could have been caused by herpes simplex virus (HSV), but the clinical conditions caused by this virus have only been described in more detail over the past 3 centuries. Most of the key findings relating to HSV infection and treatment have been made since the early 20th Century. These range from discovering some of the mechanisms behind virus l...

In the 1980s the outcome of patients with herpes simplex encephalitis was shown to be dramatically improved with aciclovir treatment. Delays in starting treatment, particularly beyond 48 h after hospital admission, are associated with a worse prognosis. Several comprehensive reviews of the investigation and management of encephalitis have been published. However, their impact on day-to-day clin...

Las conjuntivitis y oftalmias neonatales poseen diversas etiologías, entre ellas las virales. Dentro de éstas, debido a la potencial gravedad, destaca provocada por el Virus Herpes Simple, tanto serotipo 1 como 2. Se trata una entidad rara, poco frecuente, pero con alta tasa morbimortalidad no mediar diagnóstico tratamiento oportuno. Objetivo: Describir un caso oftalmia neonatal tipo I, sus car...

Encephalitis is a disease characterised by inflammation of the encephalon. An important element to take into account in this pathology that it has several causes, among which viral and metabolic are most important. This clinical picture generally manifests itself with headache, altered mental state, seizures, focal signs, movement disorders, some cases also manifested meningeal or cortical depe...

Introducción: La encefalitis autoinmune comprende un amplio espectro de desórdenes inmunológicos, entre ellos el anti-NMDAR es más frecuente. El manejo esta patología complejo debido a múltiples circunstancias. Reporte caso: Mujer 19 años que inicia cuadro subagudo con trastorno conductual y neurológico asociado: Alucinaciones, heteroagresividad, mutismo acinético, crisis epilépticas, discinesi...

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) emerged in December 2019. Beside insufficiency, neurological complications have been observed with COVID-19. Here, we report a case of meningo-encephalitis following Covid-19 infection who decompensated Neuro-Behçet’s disease. Case Presentation: A 45-year-old-man which is followed for Neuro-Behçet disease, hospitalized t...