Depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. Acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. Reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. Th...

BACKGROUND Considering the anti-oxidant properties of Pistacia atlantica and lack of data regarding its efficacy in the treatment of ulcerative colitis, this study aims at investigating the effect of the Pistacia atlantica fruit extract in treating experimentally induced colitis in a rat model. METHODS Seventy male Sprague-Dawley rats (weighing 220±20 g) were used. All rats fasted 24 hours be...

Fumaria capreolata is used in traditional medicine in North Africa for its gastrointestinal and anti-inflammatory activities. The present study investigates the effects of total alkaloids extracted from the aerial parts of Fumaria capreolata (AFC) on LPS-induced production of proinflammatory mediators (IL-6, IL-1β, iNOS, TNF-α, COX-2, and MIP-2) in RAW264.7 cells. AFC significantly reduced the ...

Development of ulcerative colitis was accompanied by the activation of iNOS/COX-2/5-LOX and increased contents of nitric oxide (NO), prostaglandin E₂ (PGE₂), and leukotriene B₄ (LTB₄). The following information was assessed: morphological changes, activity of nitric oxide-synthase, content of nitric oxide, and indexes of lipoperoxidation processes in the mucous membrane of the large intestine (...

kelussia odoratissima mozaff. is an iranian endangered endemic edible plant with enormous use in the middle region of iran as food and spice especially yogurt seasoning, and as medicinal herb for anti-inflammatory and cardiovascular purposes. antioxidant, anti-inflammatory, antihyperlipidemic properties of kelussia suggest that it may have beneficial effects on inflammatory bowel diseases like ...

background and objectives: baneh tree or pistacia atlantica subsp. kurdica is an endemic plant of iran which belongs to anacardiaceae family. it has various traditional uses including astringent and anti-diarrheal as well as improving some of the symptoms of gastrointestinal upsets. in this study we decided to investigate the effects of various fractions of baneh gum with different doses in an ...

BACKGROUND/AIMS Reactive oxygen species have a known potent role in the pathogenesis of ulcerative colitis. Iloprost, a pharmaceutical, is a chemically stable derivative of a naturally- occurring human prostacyclin. Several studies have demonstrated protective effects of iloprost via its antioxidant and its anti-inflammatory activity. The aim of this study is to evaluate the effects of iloprost...