BACKGROUND There is a worldwide increase in the prevalence of obesity and disturbances in glucose metabolism. The aim of this study was to assess the current prevalence of obesity, central obesity and abnormal glucose tolerance in Finnish population, and to investigate the associations between body mass index (BMI), waist circumference and abnormal glucose tolerance. METHODS A cross-sectional...

The global public health focus is gradually concentrating more on the non-communicable diseases (NCDs), owing to the progressively increasing trend in the burden of NCDs worldwide including the developing countries. Among these NCDs, the silent epidemic of diabetes currently has become one of the most worrisome public health concerns [1-3]. Diabetes mellitus is a heterogeneous metabolic syndrom...

A series of 45 patients who had a myocardial infarction before the age of 45 years has been studied and investigated for alterations of glucose tolerance, as shown by standard and prednisolone-primed glucose tolerance tests. Abnormal responses to standard glucose tolerance tests and prednisolone-primed glucose tolerance tests were obtained in 75.5 per cent of patients with myocardial infarction...

The natural history of diabetes mellitus can be arbitrarily divided into four stages based on the presence or absence of abnormal carbohydrate metabolism. Overt diabetes is the most advanced stage, characterized by elevated fasting blood glucose concentration and classical symptoms. This stage is divided into ketotic and nonketotic forms. Preceding overt diabetes is the latent or chemical diabe...

Dopaminergic signaling is one of the regulatory pathways being investigated for its implication in glucose metabolism. The aim of this study was to determine the effect of cabergoline on biochemical and anthropometric parameters in prediabetes stage (impaired fasting glucose and impaired glucose tolerance). In this double blind, placebo-controlled, pilot study, 27 prediabetic adults were random...

introduction: many of the diseases of adulthood are originated from the intrauterine conditions during fetal life. because of the importance of thyroid hormones in growth and development of the fetus, the effects of maternal hypothyroidism on carbohydrate metabolism in adulthood was investigated. methods: pregnant rats were divided into the fetal hypothyroidism (fh) and the control (c) groups. ...

Circulating tumor cells (CTCs) play an essential role in metastasis and serve as important prognostic biomarker. The technology of CTC labeling detection vivo can greatly improve the research cancer therapy. However, there is no to detect CTCs clinic. In this study, we demonstrate that 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-d-glucose (2-NBDG), a 2-deoxy-glucose analog, work ind...

A 34 year old man presented with an 8 year history of mild muscle pain and stiffness on exertion especially in the cold. Clinical examination was normal. Apart from a mild persistent leucocytosis, his routine investigations were normal including creatine kinase activity, electromyography and nerve conduction studies. An ischaemic exercise test produced a slow and incomplete rise in lactate. His...

Obesity and related metabolic alterations have been implicated to play a role in colorectal cancer risk. The metabolic syndrome, as assessed according to current international definitions by the key components, abdominal obesity, dyslipidemia, elevated blood pressure, and abnormal glucose metabolism, is associated with colorectal cancer. Recent studies suggest that abdominal obesity and abnorma...

OBJECTIVE Increased serum ferritin levels and iron stores may be involved in the development of abnormal glucose tolerance in women presenting with obesity and/or polycystic ovary syndrome (PCOS). We aimed to study the determinants of serum ferritin levels in premenopausal women among indexes of insulin resistance, adiposity, hyperandrogenism, and genotypes pertaining to inflammation, oxidative...