نتایج جستجو برای: abetalipoproteinemia
تعداد نتایج: 433 فیلتر نتایج به سال:
We investigated high density lipoprotein (HDL) subfractions in abetalipoproteinemia (ABL) using rate zonal ultracentrifugation. In ABL, HDL2 is the major subfraction, 65% of total mass compared to less than 10% in normal subjects with similar HDL levels. HDL2 and HDL3 in ABL (n = 3) are larger and lighter than in normals (n = 3), with mean diameters of 136 +/- 19 A and 100 +/- 12 A, respectivel...
The ABL 500 blood gas analyser from Radiometer has cordless electrodes and does not use a humidifier for calibrating gases. During the evaluation of the analytical performance of this instrument, the problem of p0(2) accuracy was approached by comparing the values obtained with two kinds of tonometry (film and bubble). An acceptable level of imprecision was demonstrated for all measured paramet...
This paper describes a model system for studying the autocatalytic phosphorylation of an immobilized substrate by a kinase enzyme. This work uses self-assembled monolayers (SAMs) of alkanethiolates on gold to present the peptide substrate on a planar surface. Treatment of the monolayer with Abl kinase results in phosphorylation of the substrate. The phosphorylated peptide then serves as a ligan...
The aims of the study were to characterize the magnitude of clearance changes during pregnancy for multiple antiepileptic drugs (AEDs) and to assess seizure frequency and factors increasing seizure risk in pregnant women with epilepsy. A retrospective analysis was performed for 115 pregnancies in 95 women with epilepsy followed at the Emory Epilepsy Center between 1999 and 2012. Antiepileptic d...
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International Partnership for Microbicides, , Silver Spring, Maryland, USA; Huntingdon Life 6 Sciences, Huntingdon Research Centre, Huntingdon, Cambridgeshire, UK; ABL B.V., Assen, The 7 Netherlands; University of Pittsburgh, Magee Womens Research Institute, Pittsburgh, PA,USA. 8 9 Running Head: Sheep model of microbicide safety and pharmacokinetics 10 11 # Address correspondence to Jonathon D....
c-Abl kinase is maintained in its normal inactive state in the cell through an assembled, compact conformation. We describe two chemical series that bind to the myristoyl site of the c-Abl kinase domain and stimulate c-Abl activation. We hypothesize that these molecules activate c-Abl either by blocking the C-terminal helix from adopting a bent conformation that is critical for the formation of...
A relatively rapid procedure is described for the spectrophotometric determination of total tocopherol in red blood cells (RBC) based on a modification of the original Emmerie-Engel reaction. The critical feature in this method is the presence of a large amount of an added antioxidant, pyrogallol or ascorbic acid, during the saponification and extraction stages and the use of thin-layer chromat...
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