Abstract Mixed phenotype acute leukemia (MPAL) is an uncommon disease characterized by currently only limited knowledge concerning biology, clinical presentation, and treatment outcome. We here describe a most unusual case of simultaneous occurrence T-lymphoblastic lymphoma in cervical mediastinal lymph nodes myeloid the bone marrow (BM) successfully treated with allogeneic stem cell transplant...

Aberrant expression of miRNAs is associated with phenotypes of various cancers, including pancreatic cancer. However, the mechanism of the aberrant expression is largely unknown. Activation of the mitogen-activated protein kinase (MAPK) signaling pathway plays a crucial role in gene expression related to themalignant phenotype of pancreatic cancer. Hence, we studied the role of MAPK in the aber...

Aberrant expression of microRNAs (miRNA) is associated with phenotypes of various cancers, including pancreatic cancer. However, the mechanism of the aberrant expression is largely unknown. Activation of the mitogen-activated protein kinase (MAPK) signaling pathway plays a crucial role in gene expression related to the malignant phenotype of pancreatic cancer. Hence, we studied the role of MAPK...

Aberrant expression of microRNAs (miRNA) is associated with phenotypes of various cancers, including pancreatic cancer. However, the mechanism of the aberrant expression is largely unknown. Activation of the mitogen-activated protein kinase (MAPK) signaling pathway plays a crucial role in gene expression related to the malignant phenotype of pancreatic cancer. Hence, we studied the role of MAPK...

Cumulus oophorus cells play an essential role in oocyte development. They are also widely employed as donor cells for cloning by somatic cell nuclear transfer. Our previous studies revealed that Cbx4 mRNA was overexpressed in cloned two-cell embryos. These data indicated that CBX4 may regulate normal cumulus cell differentiation and that its overexpression in clones could contribute to aberrant...

A key challenge in cancer genomics is the identification and prioritization of genomic aberrations that potentially act as drivers of cancer. In this paper we introduce HIT’nDRIVE, a combinatorial method to identify aberrant genes that can collectively influence possibly distant “outlier” genes based on what we call the “random-walk facility location” (RWFL) problem on an interaction network. R...

Aged, healthy skin contains cells with cancer-associated mutations yet remains aphenotypic, suggesting flexible management of oncogenic stress during homeostasis. Our lab found β-catenin expression in follicular epidermis induced aberrant growths that regressed. Although a hallmark epithelial derived tumors is loss homeostatic tissue organization, the not only resisted malignant transformation,...

Abstract There has been considerable interest in understanding the biological consequence and therapeutic implications of aberrant tryptophan metabolism brain tumors neurodegenerative diseases. An overwhelming majority this work focused on first-step (kynurenine); however, yet to result clinical application. Using global metabolomic profiling >100 patient-derived tumors, we identified a ...

Aberrant mechanotransduction and compromised epithelial barrier function are associated with numerous human pathologies including inflammatory skin disorders. However, the involved molecular mechanisms not well understood. We investigated alterations in cell-cell adhesions, mechanosensitive effector molecules mechanosignaling epidermis during inflammation using psoriasis as a model disease. Pso...