Synthetic peptides corresponding to cDNA-deduced amino acid sequences unique to the human and mouse retinoic acid receptor gamma 1 (hRAR-gamma 1 and mRAR-gamma 1, respectively) were used to generate anti-RAR-gamma 1 antibodies. Four mAbs were selected, which were directed against peptides found in region A1 (Ab1 gamma (A1)), region F (Ab2 gamma (mF) and Ab4 gamma (hF)) and region D2 (Ab5 gamma ...

Performance of the thermally-driven metal hydride hydrogen compressor (MHHC) is defined by (a) its H2 compression ratio and maximum output pressure; (b) throughput productivity/average flow rate; (c) specific thermal energy consumption which determines efficiency. In earlier studies, focus R&D efforts was on optimisation design MH containers heat mass transfer in storage system aimed at shorten...

One of the earliest theorems in category theory stated that an abelian category could be represented faithfully by exact functors into the category Ab of abelian groups [Freyd, 1964], [Lubkin, 1961] and [Heron, unpublished]. Then Mitchell [1965] showed that every such category had a full exact embedding into a module category. An equivalent formulation is that every abelian category into a cate...

The major virulence factor of Shiga toxin producing E. coli, is Shiga toxin (Stx), an AB5 toxin that consists of a ribosomal RNA-cleaving A-subunit surrounded by a pentamer of receptor-binding B subunits. The two major isoforms, Stx1 and Stx2, and Stx2 variants (Stx2a-h) significantly differ in toxicity. The exact reason for this toxicity difference is unknown, however different receptor bindin...

BACKGROUND Stx toxin is a member of the AB5 family of bacterial toxins: the active A subunit has N-glycosidase activity against 28S rRNA, resulting in inhibition of protein synthesis in eukaryotic cells, and the pentamer ligand B subunits (StxB) bind to globotria(tetra)osylceramide receptors (Gb3/Gb4) on the cell membrane. Shiga toxin-producing Escherichia coli strains (STEC) may produce Stx1 a...