OBJECTIVE To evaluate transcranial magnetic stimulation (TMS) measures of inhibition and excitation in obsessive-compulsive disorder (OCD), major depressive disorder (MDD) and schizophrenia (SCZ). METHODS Paradigms included: short-interval cortical inhibition (SICI), cortical silent period (CSP), resting motor threshold, intracortical facilitation, and motor evoked potential amplitude. A lite...

The role of A/G polymorphism at nucleotide -1082 in the interleukin-10 (IL-10) promoter was assessed by following the disease course of 253 patients who had had a routine diagnostic Hybrid Capture human papillomavirus (HPV) test because of cytologic or colposcopic abnormalities of the uterine cervix. At baseline, 97 (78%) of the 125 high-risk HPV-positive and 83 (65%) of the 128 HPV-negative pa...

The reported association of the CDKAL1 rs7754840 G/C gene polymorphism with T2DM susceptibility remains controversial. In this study, this association was further investigated using a meta-analysis of 33,149 patients and 36,992 controls from 32 independent studies. The random-effect models were used in order to evaluate the pooled odds ratios (ORs) and their 95% confidence intervals (CIs). A si...

Age (y) (95% CI) 57.5± 8.5; (53.1–61.8) 58.0± 9.0; (55.7–60.2) 56.7± 6.5; (53.4–60.0) Male (%) 10 (58.8) 43 (65.2) 12 (70.6) BMI (kg/m) (95% CI) 24.2± 5.2; (21.6–26.9) 27.0± 5.4; (25.7–28.4) 25.7± 7.1; (22.1–29.4) LVM (g) (95% CI) 95.8± 16.5*** (87.3–104.3) 164.9± 25.8 (158.6–171.3) 221.7±36.0 (203.3–240.2) LVMI (g/m) (95% CI) 33.4± 7.2*** (29.7–37.1) 57.7± 7.3 (55.8–59.5) 77.7± 10.7 (72.2–83.2...

PURPOSE Catechol-O-methyltransferase (COMT) enzyme plays a central role in estrogen-induced carcinogenesis. Emerging evidence from association studies has revealed that the functional Val158Met polymorphism (rs4680 G>A) of the Catechol-O-methyltransferase gene (COMT) has been implicated in susceptibility to breast cancer in the Chinese population, while results of individual published studies r...