Katsikatsou, M. 2013. Composite Likelihood Estimation for Latent Variable Models with Ordinal and Continuous, or Ranking Variables. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Social Sciences 86. 31 pp. Uppsala. ISBN 978-91-554-8571-9. The estimation of latent variable models with ordinal and continuous, or ranking variables is th...

Background Systemic sclerosis (SSc) is a heterogeneous autoimmune disease, with high disease-related mortality and morbidity. A subset of patients show elevated CRP levels (20-35%), which has been reported as inflammatory SSc. Preliminary data suggest that this characterized by severe phenotype. Objectives To analyse the phenotype survival compared non-inflammatory SSc patient subsets. Methods ...

Longitudinal and transverse I5N NMR relaxation times in human ubiquitin have been measured at 600MHz 'H frequency with a reproducibility of better than 1%. Two independent measurements of the 15N-{'H} NOE indicate a random error of ca. 0.01, and no values were larger than the theoretical maximum. The relaxation data are incompatible with isotropic rotational diffusion but agree well with an axi...

A family of auxiliary subunits coassemble with Slo subunit to form Ca 2 -regulated, voltage-activated BK-type K channels. The subunits play an important role in regulating the functional properties of the resulting channel protein, including apparent Ca 2 dependence and inactivation. The 3b auxiliary subunit, when coexpressed with the Slo subunit, results in a particularly rapid ( 1 ms), but in...

An auxiliary 2 subunit, when coexpressed with Slo subunits, produces inactivation of the resulting large-conductance, Ca 2 and voltage-dependent K (BK-type) channels. Inactivation is mediated by the cytosolic NH 2 terminus of the 2 subunit. To understand the structural requirements for inactivation, we have done a mutational analysis of the role of the NH 2 terminus in the inactivation process....

The ability of membrane voltage to activate high conductance, calcium-activated (BK-type) K channels is enhanced by cytosolic calcium (Ca 2 ). Activation is sensitive to a range of [Ca 2 ] that spans over four orders of magnitude. Here, we examine the activation of BK channels resulting from expression of cloned mouse Slo1 subunits at [Ca 2 ] and [Mg 2 ] up to 100 mM. The half-activation voltag...

Article5 January 2021Open Access Transparent process Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF Kaichi Yoshizaki orcid.org/0000-0002-2540-332X Department of Developmental Neuroscience, Tohoku University Graduate School Medicine, Sendai, Japan Disease Model, Aichi Disability Center, Aichi, Search for more papers by this author Ryuichi Kimura orcid.org/0000-000...