BACKGROUND Ventilator practices in patients at risk for acute lung injury (ALI) and ARDS are unclear. We examined factors associated with choice of set tidal volumes (VT), and whether VT < 8 mL/kg predicted body weight (PBW) relates to the development of ALI/ARDS. METHODS We performed a secondary analysis of a multicenter cohort of adult subjects at risk of lung injury with and without ALI/AR...

BackgroundAlemtuzumab significantly improved clinical and MRI outcomes vs. subcutaneous interferon beta-1a (SC IFNB-1a) in the CARE-MS trials (NCT00530348, NCT00548405), with sustained efficacy 2 consecutive extensions (NCT00930553, NCT02255656 [TOPAZ]).MethodsPost hoc analysis of 8-year alemtuzumab safety pooled patients (N=811) stratified by baseline age (≥18 to ≤25, >25 ≤35, >35 ≤45, >45 ≤55...

Two behavioral phenomena characterize human motor memory consolidation: diminishing susceptibility to interference by a subsequent experience and the emergence of delayed, offline gains in performance. A recent model proposes that the sleepindependent reduction in interference is followed by the sleep-dependent expression of offline gains. Here, using the fingeropposition sequence–learning task...

Recent outbreaks of bluetongue virus (BTV) serotypes 2 and 8 in many European countries provided an opportunity to investigate the possibility of improving the safety of the modified live vaccines administered mainly in South Africa. Modified live vaccines (MLV) released at a titre of 5 x 104 PFU/mL, raised concerns and prompted the need to determine the minimum titre which will still be pro...