Gcn5 protein is a prototypical histone acetyltransferase that controls transcription of multiple yeast genes. To identify molecular functions that act downstream of or in parallel with Gcn5 protein, we screened for suppressors that rescue the transcriptional defects of HIS3 caused by a catalytically inactive mutant Gcn5, the E173H mutant. One bypass of Gcn5 requirement gene (BGR) suppressor was...

Abstract Aim Improving the standard of epistaxis management in Ayrshire & Arran. Method A survey was distributed to doctors assessing their familiarity with assessment and management. Working ENT department, a teaching programme then developed aimed at improving skill nasal packing, cautery first aid, based on local guidelines. After session, all participants filled post-education questionn...

A retrospective analysis of all National Neonatal Transport Programme (NNTP) transport data from 2004-2009 was performed. 1621 transports were conducted during this period with a yearly average of 271. The majority (96%) were ground transports. 1118 (69%) were forward transfers. Of the 446 (27.5%) retrotransfers, 411 (91%.) were to tertiary centres. When transported, 592 infants (36.5%) were <4...

nosed malignancy, and second leading cause of cancer related deaths in the United States. Among them, approximately half of the patients develop incurable condition with no effective treatment. Current therapy for advanced prostate cancer is largely based on androgen deprivation. However, as with androgen ablation therapy, the responses are generally of short duration and resistant to therapy e...

We introduce a model that captures the main properties that characterize employee stock options (ESO), in particular, the likelihood of early voluntary exercise and the obligation to exercise immediately if the employee leaves the firm, except if this happens before options are vested, in which case the options are forfeited. We derive an analytic formula for the price of the ESO and analyze it...

Spectral beam combining (SBC) by volume Bragg gratings (VBGs) recorded in photo-thermo-refractive (PTR) glass is a powerful tool for laser applications that require higher radiance than a single laser unit can achieve. The beam-combining factor (BCF) is introduced as a tool to compare various beam-combining methods and experiments. It describes the change of radiance provided by a beam-combinin...

CONTEXT In low-risk differentiated thyroid cancer (DTC), postoperative (131)I remnant ablation should employ a minimum effective activity; reports increasingly suggest efficacy of low activities, e.g. 1110 MBq/30 mCi. OBJECTIVES, DESIGN, PATIENTS, AND INTERVENTIONS: We retrospectively studied the ablation capability and diagnostic utility of the Minidose protocol, two 740-MBq/20 mCi outpatient ...

Comparison of Flow Routing Algorithms Used in Geographic Information Systems Track: Water Resources Author(s): Christine Lam, John Wilson This paper reports the results of a series of experiments to evaluate the performance of five flow routing algorithms that have been implemented inside one or more GIS. A fuzzy classification was used to delineate landscape classes (hilltops, steep slopes, fo...