Ms M, a 74-year-old woman with type 2 diabetes of 6 years' duration, has a glycated hemoglobin (HbA1C) value of 7.4% despite taking 3 oral antidiabetic medications, as well as coexistent hypertension and abdominal obesity. She has no known microvascular or macrovascular complications of diabetes and is otherwise healthy. She is reluctant to commence insulin treatment as she dislikes the idea of...

Of the plethora of bioinformatical tools available, some useful tools that allow complete genome sequences to be compared are described here. Comparisons of genome length, base composition, gene density, numbers of tRNA and rRNA genes, and codon usage can provide useful biological insights. Examples are provided of a Genome Atlas plot, to summarize many features of a single genome, and a BLAST ...

In a ubiquitous computing environment of sensor networks, monitoring the frequent contexts of a user occurred by those sensors is very important to provide a proactive service to the user. Such frequent contexts of the sensors can be recognized by associations between the set of sensor values and a set of actuator operations. This paper proposes a method of generating a new type of an associati...

Pulpal conditions were studied in Chinese hamsters with hereditary diabetes mellitus, H-l-virus-modified hamsters, mice of the gray lethal mouse strain, polyoma-infected Swiss mice, mutation-diabetic mice, and rats with streptozotocin-produced diabetes. Degenerative pulpal changes in the Chinese hamsters and the polyoma-infected Swiss mice were often found in association with periodontal diseas...

The authors declare no conflict of interest. The caries-controlling or preventing effect of xylitol is more than just excluding fermentable sugars from the diet. This review aims to discuss the specific effects of xylitol which could have contributed to the results of the caries trials. Xylitol promotes mineralization by increasing the flow of saliva, an effect it has in common with all sweeten...

Rounded atelectasis is an atelectasis of a peripheral part of the lung due to pleural adhesions and fibrosis causing deformation of the lung and bending of some small bronchi. From 1970 to 1986, some 74 patients with rounded atelectasis have been seen at the Lung Department. Sixty-four of these patients had been exposed to asbestos. The lesion was secondary to a benign asbestos pleurisy in nine...

Computer Science bears approximately the same relationship to computers as Aerodynamics bears to sailboats. It describes how they work but has little impact on their design which is based almost entirely on intuition strengthened and controlled by experience. However, one day, the Wright brothers of the "ultra-computer" will get to their Kitty Hawk and Computer Science will come into its own. I...

T he Daidalos project (www. ist-daidalos.org) is employing pervasive computing to organize network and communication technologies to enhance the user experience. More specifically, Daidalos seeks to help users access services no matter where they are and to improve the user experience by accounting for contextual information and user preferences. Our motivation to improve the user experience co...

Researchers at the Weizmann Institute of Science have described an antiapoptotic signaling pathway in murine B cells that is triggered by activation of the macrophage migration inhibitor factor receptor, also called CD74. The work elucidates the mechanism of action of Immunomedics Inc.’s IMMU-110 and milatuzumab, as well as other drug candidates targeting the MIF receptor. And by delineating th...