Studies of human tissue have suggested an association between productive Epstein Barr virus and idiopathic pulmonary fibrosis (IPF). However, a pathogenic role for the virus has not been established. This study was undertaken to develop an animal model, which would explore the association between viral infection and pulmonary fibrosis. BALB/c mice (n=30), resistant to bleomycin, were primed wit...

BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a severe and progressive respiratory disease with poor prognosis. Despite the positive outcomes from recent clinical trials, there is still no cure for this disease. Pre-clinical animal models are currently largely limited to small animals which have a number of shortcomings. We have previously shown that fibrosis is induced in isolated sheep lu...

Ortiz, Luis A., Hunter C. Champion, Joseph A. Lasky, Federica Gambelli, Evelyn Gozal, Gary W. Hoyle, Mary B. Beasley, Albert L. Hyman, Mitchell Friedman, and Philip J. Kadowitz. Enalapril protects mice from pulmonary hypertension by inhibiting TNF-mediated activation of NFB and AP-1. Am J Physiol Lung Cell Mol Physiol 282: L1209–L1221, 2002. First published January 12, 2002; 10.1152/ajplung.001...

Bleomycin is well known as causative molecule for acute lung injury and interstitial pneumonia. The free radical production from bleomycin is thought to play an important role in the pathogenesis of acute lung injury and interstitial pneumonia. However, there was no direct evidence of free radical production in this model. Therefore, we examined in vivo radical production by mice treated with a...

The role of tobacco smoking in the development and outcome of pulmonary fibrosis is uncertain. To approach the effects of cigarette smoke on bleomycin-induced lung fibrosis, we studied five groups of guinea pigs: 1) controls, 2) instilled with bleomycin (B), 3) exposed to tobacco smoke for 6 wk (TS), 4) bleomycin instillation plus tobacco smoke exposure for 6 wk (B+TS), and 5) tobacco smoke exp...

Pulmonary fibrosis can be experimentally induced in small rodents by bleomycin. The antibiotic is usually administered via the intratracheal or intranasal routes. In the present study, we investigated the oropharyngeal aspiration of bleomycin as an alternative route for the induction of lung fibrosis in rats and mice. The development of lung injury was followed in vivo by ultrashort echo time m...

A case of verrucous squamous cell carcinoma of the oesophagus treated with bleomycin is reported. Bleomycin brought prompt reduction of the tumour and relief of symptoms. There have been no previous reports on experience with anti-cancer agents for verrucous carcinoma of the oesophagus. Administration of bleomycin might be an effective treatment for verrucous carcinoma of the oesophagus.

of bleomycin or its derivative peplomycin, occurs in 8-20% patients during systemic or local therapy (1). It characterised by a linear erythematous streak with hyperpigmentation (2, 3), and was first described by Moulin in 1970 (4). Herein, we present a typical case of flagellate erythema induced by Bleomycin. A 32 year-old Taiwanese male with mixed germ cell tumour of the anterior mediastinum ...

apoptosis has a critical role in the pathogenesis of bleomycin induced-pulmonary fibrosis. the severity of fibrosis varies among different strains of mice. recent studies have indicated that expression of apoptotic regulatory genes may be specific in different cell types in various strains. in this study, bleomycin-induced pulmonary apoptosis in nmri albino mice were compared with c57bl/6 black...

many studies have been performed for treatment or prevention of pulmonary fibrosis. however, no effective treatment has been found yet. the aim of this study was to investigate the effect of grape seed extract on bleomycin-induced lung fibrosis in rat. hydroalcoholic extract of grape seed (vitis vinifera) was prepared using maceration method. nmri rats weighing 250-300 g were given single intra...