AIM
To study the effects of KN-62, an inhibitor of Ca(2+)-calmodulin dependent protein kinase II (CCDPK II), on the damage of cortical neurons and mechanisms of the loss of CCDPK II activity induced by sodium glutamate (Glu).
METHODS
CCDPK II activity was measured by 32P incorporation and backphosphorylations of endogenous proteins were studied by autoradiography.
RESULTS
1) KN-62 provided ...